Plasmid maintenance and growth of recombinant Saccharomyces cerevisiae producing hepatitis B virus surface antigen

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Title
Plasmid maintenance and growth of recombinant Saccharomyces cerevisiae producing hepatitis B virus surface antigen
Author(s)
G M Lee; Ki Bang Song; Sang Ki Rhee; Moon Hi Han
Bibliographic Citation
Biotechnology Letters, vol. 8, no. 6, pp. 385-390
Publication Year
1986
Abstract
The effects of host strains (Saccharomycescerevisiae) and medium composition on the plasmid stability and expression level of hepatitis B virus surface antigen were investigated. Specific growth rates of cells carrying a plasmid, pMHBS, was found to be slower than those without the plasmid. It was also found that the plasmid was maintained in a more stable manner in the selective medium. The nonselective complex medium, however, was greatly favored for the growth of recombinant hosts as well as the HBsAg production.
ISSN
0141-5492
Publisher
Springer
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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