Protective effect of Paulownia tomentosa fruits in an experimental animal model of acute lung injury

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dc.contributor.authorSeong Man Kim-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorOk-Kyoung Kwon-
dc.contributor.authorJ H Min-
dc.contributor.authorJin Mi Park-
dc.contributor.authorDoo-Young Kim-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorS J Lee-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorJae-Won Lee-
dc.date.accessioned2022-07-29T01:07:32Z-
dc.date.available2022-07-29T01:07:32Z-
dc.date.issued2022-
dc.identifier.issn1598-642X-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/30111-
dc.description.abstractThe fruits of Paulownia tomentosa (Thunb.) (PT) Steud. have been reported to exert a variety of biological activities. A previous study confirmed that compounds isolated from PT fruits (PTF) exerted anti-inflammatory effects on TNF-α-stimulated airway epithelial cells. However, there is no report on the protective effects of PTF on acute lung injury (ALI). Here, we examined the ameliorative effects of PTF in an experimental animal model of lipopolysaccharide (LPS)-induced ALI. In ALI mice, increased levels of inflammatory cell influx were confirmed in the lungs of mice, and an increase of microphage numbers, TNF-α, IL-6 and MCP-1 production and protein content were detected in mouse bronchoalveolar lavage fluid. However, these increases were significantly reversed with PTF pretreatment. In addition, PTF inhibited the increased expression of iNOS and COX-2 in the lungs of ALI mice. Furthermore, the upregulation of MAPK and NF-κB activation was decreased in the lungs of ALI mice by PTF. In the in vitro experiment, PTF pretreatment exerted an anti-inflammatory effect by inhibiting the secretion of nitric oxide, TNF-α and IL-6 in LPS-stimulated RAW264.7 macrophages. Collectively, these results indicated that PTF has ameliorative effects on airway inflammation in an experimental animal model of ALI.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleProtective effect of Paulownia tomentosa fruits in an experimental animal model of acute lung injury-
dc.title.alternativeProtective effect of Paulownia tomentosa fruits in an experimental animal model of acute lung injury-
dc.typeArticle-
dc.citation.titleMicrobiology and Biotechnology Letters-
dc.citation.number2-
dc.citation.endPage318-
dc.citation.startPage310-
dc.citation.volume50-
dc.contributor.affiliatedAuthorSeong Man Kim-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorOk-Kyoung Kwon-
dc.contributor.affiliatedAuthorJin Mi Park-
dc.contributor.affiliatedAuthorDoo-Young Kim-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorJae-Won Lee-
dc.contributor.alternativeName김성만-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName민재홍-
dc.contributor.alternativeName박진미-
dc.contributor.alternativeName김두영-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이승진-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName이재원-
dc.identifier.bibliographicCitationMicrobiology and Biotechnology Letters, vol. 50, no. 2, pp. 310-318-
dc.identifier.doi10.48022/mbl.2112.12007-
dc.subject.keywordAcute lung injury-
dc.subject.keywordPaulownia tomentosa fruits-
dc.subject.keywordMacrophage-
dc.subject.keywordCytokines-
dc.subject.keywordNF-κB-
dc.subject.localAcute lung injury-
dc.subject.localacute lung injury-
dc.subject.localAcute Lung Injury-
dc.subject.localacute lung injury (ALI)-
dc.subject.localPaulownia tomentosa fruits-
dc.subject.localmacrophages-
dc.subject.localmacrophage-
dc.subject.localMacrophages-
dc.subject.localMacrophage-
dc.subject.localcytokine-
dc.subject.localCytokines-
dc.subject.localCytokine-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.description.journalClassN-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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