Antibodies regulate dual-function enzyme IYD to induce functional synergy between metabolism and thermogenesis

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Title
Antibodies regulate dual-function enzyme IYD to induce functional synergy between metabolism and thermogenesis
Author(s)
Sunghyun Kang; H W Park; K H Han
Bibliographic Citation
International Journal of Molecular Sciences, vol. 23, no. 14, pp. 7834-7834
Publication Year
2022
Abstract
Iodotyrosine deiodinase (IYD) is a type of deiodinase enzyme that scavenges iodide from the thyroid gland. Previously, we showed that H3 Ab acts as an agonist on IYD to induce migration of cells to the heart and differentiate human stem cells into brown adipocyte-like cells. To continue this study, we investigated the dual function of IYD in hypothyroidism by blocking IYD and in thermogenesis by looking at the induction of brown adipocyte-like cells by treatment with H3 Ab in a mouse model. Surprisingly, our results suggest H3 Ab acts on IYD as both an antagonist and agonist to reduce T4 and increase core body temperature in the mouse model. Taken together, the data suggest IYD has a dual function that can regulate physiological metabolism and enhance thermogenesis.
Keyword
AntibodyIodotyrosine deiodinase (IYD)Dual functionAntagonistHypothyroidism
ISSN
1661-6596
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms23147834
Type
Article
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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