Anti-inflammatory activity of cajanin, an isoflavonoid derivative isolated from Canavalia lineata pods = 해녀콩으로부터 분리된 Isoflavonoid 화합물의 항염증 활성
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- Anti-inflammatory activity of cajanin, an isoflavonoid derivative isolated from Canavalia lineata pods = 해녀콩으로부터 분리된 Isoflavonoid 화합물의 항염증 활성
- Su-Jin Hong; Ok-Kyoung Kwon; Daseul Hwang; Soo Hyun Goo; Doo-Young Kim; M H Kim; S Y Kim; Hyun-Jae Jang; Sei-Ryang Oh
- Bibliographic Citation
- International Journal of Molecular Sciences, vol. 23, no. 16, pp. 9492-9492
- Publication Year
- The bioactive components of Canavalia lineata (Thunb.) DC pods were investigated using bioactivity-guided isolation, and the chemical structures of flavonoids 1-3, isoflavonoid derivatives 4-11, and phenolic compounds 12 and 13 were identified by comparing NMR, MS, and CD spectral data with previously reported spectroscopic data. Compounds 1-13 were evaluated for their anti-inflammatory effects on LPS-stimulated RAW264.7 macrophages. Among these compounds, the isoflavonoid derivative cajanin (7) exhibited the most potent anti-inflammatory activity (IC50 of NO = 19.38 ± 0.05 μM; IC50 of IL-6 = 7.78 ± 0.04 μM; IC50 of TNF-α = 26.82 ± 0.11 μM), exerting its anti-inflammatory effects by suppressing the activation and nuclear translocation of the transcription factor NF-κB by phosphorylating IκB and p65. These results suggested that cajanin (7) may be a potential candidate for improving the treatment of inflammatory diseases.
- Canavalia lineataIsoflavonoidCajaninAnti-inflammation
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- Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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