Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance

Cited 6 time in scopus
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Title
Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance
Author(s)
Y J Choe; J Y Min; H Lee; S Y Lee; J Kwon; H J Kim; J Lee; H M Kim; H S Park; M Y Cho; J Y Hyun; H M Kim; Y H Chung; S K Ha; H G Jeong; In Pyo Choi; Tae-Don Kim; K S Hong; E H Han
Bibliographic Citation
iScience, vol. 25, no. 9, pp. 105017-105017
Publication Year
2022
Abstract
The heterotypic CIC structures formed of cancer and immune cells have been observed in tumor tissues. We aimed to assess the feasibility of using heterotypic CICs as a functional biomarker to predict NK susceptibility and drug resistance. The heterotypic CIC-forming cancer cells showed a lower response to NK cytotoxicity and higher proliferative ability than non-CIC cancer cells. After treatment with anticancer drugs, cancer cells that formed heterotypic CICs showed a higher resistance to anticancer drugs than non-CIC cancer cells. We also observed the formation of more CIC structures in cancer cells treated with anticancer drugs than in the non-treated group. Our results confirm the association between heterotypic CIC structures and anticancer drug resistance in CICs formed from NK and cancer cells. These results suggest a mechanism underlying immune evasion in heterotypic CIC cancer cells and provide insights into the anticancer drug resistance of cancer cells.
ISSN
2589-0042
Publisher
Elsevier-Cell Press
DOI
http://dx.doi.org/10.1016/j.isci.2022.105017
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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