Cited 6 time in
- Title
- Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance
- Author(s)
- Y J Choe; J Y Min; H Lee; S Y Lee; J Kwon; H J Kim; J Lee; H M Kim; H S Park; M Y Cho; J Y Hyun; H M Kim; Y H Chung; S K Ha; H G Jeong; In Pyo Choi; Tae-Don Kim; K S Hong; E H Han
- Bibliographic Citation
- iScience, vol. 25, no. 9, pp. 105017-105017
- Publication Year
- 2022
- Abstract
- The heterotypic CIC structures formed of cancer and immune cells have been observed in tumor tissues. We aimed to assess the feasibility of using heterotypic CICs as a functional biomarker to predict NK susceptibility and drug resistance. The heterotypic CIC-forming cancer cells showed a lower response to NK cytotoxicity and higher proliferative ability than non-CIC cancer cells. After treatment with anticancer drugs, cancer cells that formed heterotypic CICs showed a higher resistance to anticancer drugs than non-CIC cancer cells. We also observed the formation of more CIC structures in cancer cells treated with anticancer drugs than in the non-treated group. Our results confirm the association between heterotypic CIC structures and anticancer drug resistance in CICs formed from NK and cancer cells. These results suggest a mechanism underlying immune evasion in heterotypic CIC cancer cells and provide insights into the anticancer drug resistance of cancer cells.
- ISSN
- 2589-0042
- Publisher
- Elsevier-Cell Press
- DOI
- http://dx.doi.org/10.1016/j.isci.2022.105017
- Type
- Article
- Appears in Collections:
- Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
- Files in This Item:
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