DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seon Gyeong Bak | - |
dc.contributor.author | Hyung-Jin Lim | - |
dc.contributor.author | Yeong-Seon Won | - |
dc.contributor.author | Soyoung Lee | - |
dc.contributor.author | S H Cheong | - |
dc.contributor.author | S J Lee | - |
dc.contributor.author | E Y Bae | - |
dc.contributor.author | Seung Woong Lee | - |
dc.contributor.author | Seung Jae Lee | - |
dc.contributor.author | Mun Chual Rho | - |
dc.date.accessioned | 2022-09-19T16:33:02Z | - |
dc.date.available | 2022-09-19T16:33:02Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/30365 | - |
dc.description.abstract | Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases. | - |
dc.publisher | Hindawi Ltd | - |
dc.title | Regulatory effects of Lycium barbarum extract and isolated scopoletin on atopic dermatitis-like skin inflammation | - |
dc.title.alternative | Regulatory effects of Lycium barbarum extract and isolated scopoletin on atopic dermatitis-like skin inflammation | - |
dc.type | Article | - |
dc.citation.title | Biomed Research International | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 2475699 | - |
dc.citation.startPage | 2475699 | - |
dc.citation.volume | 2022 | - |
dc.contributor.affiliatedAuthor | Seon Gyeong Bak | - |
dc.contributor.affiliatedAuthor | Hyung-Jin Lim | - |
dc.contributor.affiliatedAuthor | Yeong-Seon Won | - |
dc.contributor.affiliatedAuthor | Soyoung Lee | - |
dc.contributor.affiliatedAuthor | Seung Woong Lee | - |
dc.contributor.affiliatedAuthor | Seung Jae Lee | - |
dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
dc.contributor.alternativeName | 박선경 | - |
dc.contributor.alternativeName | 임형진 | - |
dc.contributor.alternativeName | 원영선 | - |
dc.contributor.alternativeName | 이소영 | - |
dc.contributor.alternativeName | 정선희 | - |
dc.contributor.alternativeName | 이성진 | - |
dc.contributor.alternativeName | 배은영 | - |
dc.contributor.alternativeName | 이승웅 | - |
dc.contributor.alternativeName | 이승재 | - |
dc.contributor.alternativeName | 노문철 | - |
dc.identifier.bibliographicCitation | Biomed Research International, vol. 2022, pp. 2475699-2475699 | - |
dc.identifier.doi | 10.1155/2022/2475699 | - |
dc.description.journalClass | Y | - |
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