Antifertility effect of progestrone antibodies in mice

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dc.contributor.authorDo Young Yoon-
dc.contributor.authorJae Wha Kim-
dc.contributor.authorS W Hwang-
dc.contributor.authorM J Choi-
dc.contributor.authorIn Seong Choe-
dc.contributor.authorJ B Kim-
dc.contributor.authorTai Wha Chung-
dc.date.accessioned2017-04-19T08:43:50Z-
dc.date.available2017-04-19T08:43:50Z-
dc.date.issued1989-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/3036-
dc.description.abstractEarly embryo development and implantation were arrested in ICR mice which were passively immunized with a mouse monoclonal progesterone antibody given as a single intraperitoneal injection at 12 hrs or 60 hrs post coitum (p.c.). Unimplanted embryos were recovered from the reproductive tract of the antibody-treated mice and none of these progressed to the blastocyst stage. The most pronounced effect was an arrest of embryonic development at a stage prior to cavitation. The plasma progesterone concentration in the blood taken by cardiac puncture increased greatly after the treatment by virtue of high affinity binding by the antibody in circulation. The results showed that passive immunization against progesterone shortly after mating interfered with early hormone dependent steps which were essential for normal embryonic development.-
dc.publisherPharmaceutical Soc Korea-
dc.titleAntifertility effect of progestrone antibodies in mice-
dc.title.alternativeAntifertility effect of progestrone antibodies in mice-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number4-
dc.citation.endPage275-
dc.citation.startPage269-
dc.citation.volume12-
dc.contributor.affiliatedAuthorDo Young Yoon-
dc.contributor.affiliatedAuthorJae Wha Kim-
dc.contributor.affiliatedAuthorIn Seong Choe-
dc.contributor.affiliatedAuthorTai Wha Chung-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName김재화-
dc.contributor.alternativeName황수원-
dc.contributor.alternativeName최명자-
dc.contributor.alternativeName최인성-
dc.contributor.alternativeName김종배-
dc.contributor.alternativeName정태화-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 12, no. 4, pp. 269-275-
dc.identifier.doi10.1007/BF02911059-
dc.subject.keywordProgesterone-
dc.subject.keywordantifertility-
dc.subject.keywordpassive immunization-
dc.subject.keywordprogesterone monoclonal antibodies-
dc.subject.keywordprogesterone EIA-
dc.subject.localProgesterone-
dc.subject.localprogesterone-
dc.subject.localantifertility-
dc.subject.localpassive immunization-
dc.subject.localprogesterone monoclonal antibodies-
dc.subject.localprogesterone EIA-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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