New multidrug efflux systems in a microcystin-degrading bacterium Blastomonas fulva and its genomic feature

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dc.contributor.authorL Jin-
dc.contributor.authorC Cui-
dc.contributor.authorC Zhang-
dc.contributor.authorSo-Ra Ko-
dc.contributor.authorT Li-
dc.contributor.authorF J Jin-
dc.contributor.authorChi-Yong Ahn-
dc.contributor.authorHee-Mock Oh-
dc.contributor.authorHyung Gwan Lee-
dc.date.accessioned2022-09-26T16:32:31Z-
dc.date.available2022-09-26T16:32:31Z-
dc.date.issued2022-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/30381-
dc.description.abstractA microcystin-degrading bacterial strain, Blastomonas fulva T2, was isolated from the culture of a microalgae Microcystis. The strain B. fulva T2 is Gram-stain-negative, non-motile, aerobic, non-spore-forming and phototrophic. The cells of B. fulva T2 are able to grow in ranges of temperature from 15 to 37 °C, with a pH of 6 to 8 and a salinity of 0 to 1% NaCl. Here, we sequenced the complete genome of B. fulva T2, aiming to better understand the evolutionary biology and the function of the genus Blastomonas at the molecular level. The complete genome of B. fulva T2 contained a circular chromosome (3,977,381 bp) with 64.3% GC content and a sizable plasmid (145.829 bp) with 60.7% GC content which comprises about 3.5% of the total genetic content. A total of 3842 coding genes, including 46 tRNAs and 6 rRNAs, were predicted in the genome. The genome contains genes for glycolysis, citric acid cycle, Entner-Doudoroff pathways, photoreaction center and bacteriochlorophylla synthesis. A 7.9 K gene cluster containing mlrA, mlrB, mlrC and mlrD1,2,3,4 of microcystin-degrading enzymes was identified. Notably, eight different efflux pumps categorized into RND, ABC and MFS types have been identified in the genome of strain T2. Our findings should provide new insights of the alternative reaction pathway as well as the enzymes which mediated the degradation of microcystin by bacteria, as well as the evolution, architectures, chemical mechanisms and physiological roles of the new bacterial multidrug efflux system.-
dc.publisherMDPI-
dc.titleNew multidrug efflux systems in a microcystin-degrading bacterium Blastomonas fulva and its genomic feature-
dc.title.alternativeNew multidrug efflux systems in a microcystin-degrading bacterium Blastomonas fulva and its genomic feature-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.number18-
dc.citation.endPage10856-
dc.citation.startPage10856-
dc.citation.volume23-
dc.contributor.affiliatedAuthorSo-Ra Ko-
dc.contributor.affiliatedAuthorChi-Yong Ahn-
dc.contributor.affiliatedAuthorHee-Mock Oh-
dc.contributor.affiliatedAuthorHyung Gwan Lee-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeNameCui-
dc.contributor.alternativeNameZhang-
dc.contributor.alternativeName고소라-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName안치용-
dc.contributor.alternativeName오희목-
dc.contributor.alternativeName이형관-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, vol. 23, no. 18, pp. 10856-10856-
dc.identifier.doi10.3390/ijms231810856-
dc.subject.keywordBlastomonas fulva-
dc.subject.keywordMicrocystin degradation-
dc.subject.keywordMultidrug efflux system-
dc.subject.keywordRND pumps-
dc.subject.keywordMFS-
dc.subject.keywordABC transporter-
dc.subject.localBlastomonas fulva-
dc.subject.localABC transporter-
dc.description.journalClassY-
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Synthetic Biology and Bioengineering Research Institute > Cell Factory Research Center > 1. Journal Articles
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