Agathobaculum butyriciproducens shows neuroprotective effects in a 6-OHDA-induced mouse model of Parkinson's disease

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Agathobaculum butyriciproducens shows neuroprotective effects in a 6-OHDA-induced mouse model of Parkinson's disease
Da Woon Lee; Young-Kyoung Ryu; Dong-Ho Chang; Hye Yeon Park; Jun Go; So Young Maeng; D Y Hwang; Byoung Chan KimChul-Ho LeeKyoung Shim Kim
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 32, no. 9, pp. 1168-1177
Publication Year
Parkinson's disease (PD) is the second-most prevalent neurodegenerative disease and is characterized by dopaminergic neuronal death in the midbrain. Recently, the association between alterations in PD pathology and the gut microbiota has been explored. Microbiota-targeted interventions have been suggested as a novel therapeutic approach for PD. Agathobaculum butyriciproducens SR79T (SR79) is an anaerobic bacterium. Previously, we showed that SR79 treatment induced cognitive improvement and reduced Alzheimer's disease pathologies in a mouse model. In this study, we hypothesized that SR79 treatment may have beneficial effects on PD pathology. To investigate the therapeutic effects of SR79 on PD, 6-hydroxydopamine (6-OHDA)-induced mouse models were used. D-Amphetamine sulfate (d-AMPH)-induced behavioral rotations and dopaminergic cell death were analyzed in unilateral 6-OHDA-lesioned mice. Treatment with SR79 significantly decreased ipsilateral rotations induced by d-AMPH. Moreover, SR79 treatment markedly activated the AKT/GSK3β signaling pathway in the striatum. In addition, SR79 treatment affected the Nrf2/ARE signaling pathway and its downstream target genes in the striatum of 6-OHDA-lesioned mice. Our findings suggest a protective role of SR79 in 6-OHDA-induced toxicity by regulating the AKT/Nrf2/ARE signaling pathway and astrocyte activation. Thus, SR79 may be a potential microbe-based intervention and therapeutic strategy for PD.
Oxidative stressInflammationSR79Mouse modelParkinson’s disease
Korea Soc-Assoc-Inst
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Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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