Hygrolansamycins A-D, O-heterocyclic macrolides from Streptomyces sp. KCB17JA11

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Title
Hygrolansamycins A-D, O-heterocyclic macrolides from Streptomyces sp. KCB17JA11
Author(s)
Jun-Pil Jang; Byeongsan Lee; Kyung Taek Heo; Tae Hoon Oh; Hyeok Won LeeSung-Kyun Ko; B Y Hwang; Jae-Hyuk JangYoung-Soo Hong
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 32, no. 10, pp. 1299-1306
Publication Year
2022
Abstract
Six ansamycin derivatives were isolated from the culture broth of Streptomyces sp. KCB17JA11, including four new hygrolansamycins A-D (1-4) and known congeners divergolide O (5) and hygrocin C (6). Compounds 1-5 featured an unusual six-membered O-heterocyclic moiety. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The structures of 1-4 were elucidated using NMR and HRESIMS experiments, and the absolute configuration was established by the Mosher’s method. Compound 2 exhibited mild cytotoxicity against five cancer cell lines with IC50 values ranging from 24.60 ± 3.37 μM to 49.93 ± 4.52 μM.
Keyword
Molecular networkingStreptomycesAnsamycin familyHygrolansamycin
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4014/jmb.2206.06039
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
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