Targeting ERRα promotes cytotoxic effects against acute myeloid leukemia through suppressing mitochondrial oxidative phosphorylation

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dc.contributor.authorW Seo-
dc.contributor.authorS Yoo-
dc.contributor.authorY Zhong-
dc.contributor.authorS H Lee-
dc.contributor.authorY S Woo-
dc.contributor.authorH S Choi-
dc.contributor.authorMinho Won-
dc.contributor.authorT Roh-
dc.contributor.authorS M Jeon-
dc.contributor.authorK T Kim-
dc.contributor.authorP Silwal-
dc.contributor.authorM J Lee-
dc.contributor.authorJ Y Heo-
dc.contributor.authorN Lawlor-
dc.contributor.authorS Kim-
dc.contributor.authorD Lee-
dc.contributor.authorJ M Kim-
dc.contributor.authorI C Song-
dc.contributor.authorJ Zhu-
dc.contributor.authorE K Jo-
dc.date.accessioned2022-10-28T16:32:36Z-
dc.date.available2022-10-28T16:32:36Z-
dc.date.issued2022-
dc.identifier.issn1756-8722-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/30514-
dc.description.abstractAcute myeloid leukemia (AML) is an aggressive blood cancer with poor clinical outcomes. Emerging data suggest that mitochondrial oxidative phosphorylation (mtOXPHOS) plays a significant role in AML tumorigenesis, progression, and resistance to chemotherapies. However, how the mtOXPHOS is regulated in AML cells is not well understood. In this study, we investigated the oncogenic functions of ERRα in AML by combining in silico, in vitro, and in vivo analyses and showed ERRα is a key regulator of mtOXPHOS in AML cells. The increased ERRα level was associated with worse clinical outcomes of AML patients. Single cell RNA-Seq analysis of human primary AML cells indicated that ERRα-expressing cancer cells had significantly higher mtOXPHOS enrichment scores. Blockade of ERRα by pharmacologic inhibitor (XCT-790) or gene silencing suppressed mtOXPHOS and increased anti-leukemic effects in vitro and in xenograft mouse models.-
dc.publisherSpringer-BMC-
dc.titleTargeting ERRα promotes cytotoxic effects against acute myeloid leukemia through suppressing mitochondrial oxidative phosphorylation-
dc.title.alternativeTargeting ERRα promotes cytotoxic effects against acute myeloid leukemia through suppressing mitochondrial oxidative phosphorylation-
dc.typeArticle-
dc.citation.titleJournal of Hematology & Oncology-
dc.citation.number0-
dc.citation.endPage156-
dc.citation.startPage156-
dc.citation.volume15-
dc.contributor.affiliatedAuthorMinho Won-
dc.contributor.alternativeName서원영-
dc.contributor.alternativeName유승열-
dc.contributor.alternativeNameZhong-
dc.contributor.alternativeName이상희-
dc.contributor.alternativeName우수연-
dc.contributor.alternativeName최희선-
dc.contributor.alternativeName원민호-
dc.contributor.alternativeNameRoh-
dc.contributor.alternativeName전상민-
dc.contributor.alternativeName김경태-
dc.contributor.alternativeNameSilwal-
dc.contributor.alternativeName이민정-
dc.contributor.alternativeName허준영-
dc.contributor.alternativeNameLawlor-
dc.contributor.alternativeName김섭-
dc.contributor.alternativeName이동준-
dc.contributor.alternativeName김진만-
dc.contributor.alternativeName송익찬-
dc.contributor.alternativeNameZhu-
dc.contributor.alternativeName조은경-
dc.identifier.bibliographicCitationJournal of Hematology & Oncology, vol. 15, pp. 156-156-
dc.identifier.doi10.1186/s13045-022-01372-7-
dc.subject.keywordAML-
dc.subject.keywordERRα-
dc.subject.keywordMitochondrial oxidative phosphorylation-
dc.subject.keywordApoptosis-
dc.subject.localAML-
dc.subject.localmitochondrial oxidative phosphorylation-
dc.subject.localMitochondrial oxidative phosphorylation-
dc.subject.localApoptosis-
dc.subject.localapoptosis-
dc.description.journalClassY-
Appears in Collections:
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
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