Application of nanopore sensors for biomolecular interactions and drug discovery

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Title
Application of nanopore sensors for biomolecular interactions and drug discovery
Author(s)
Ki Baek JeongJin Sik Kim; Naresh Niranjan Dhansekar; Mi-Kyung LeeSeung-Wook Chi
Bibliographic Citation
Chemistry-An Asian Journal, vol. 17, pp. e202200679-e202200679
Publication Year
2022
Abstract
Biomolecular interactions, such as protein-protein, protein-nucleic acid, and protein/nucleic acid-ligand interactions, play crucial roles in various cellular signaling and biological processes, and offer attractive therapeutic targets in numerous human diseases. Currently, drug discovery is limited by the low efficiency and high cost of conventional ensemble-averaging-based techniques for biomolecular interaction analysis and high-throughput drug screening. Nanopores are an emerging technology for single-molecule sensing of biomolecules. Owing to the notable merits of single-molecule sensing, nanopore sensors have contributed tremendously to nucleic acid sequencing and disease diagnostics. In this minireview, we summarize the recent developments and outlooks in single-molecule sensing of various biomolecular interactions for drug discovery applications using biological and solid-state nanopore sensors.
ISSN
1861-4728
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/asia.202200679
Type
Article
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > 1. Journal Articles
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