Determination of the unilaterally damaged region may depend on the asymmetry of carotid blood flow velocity in hemiparkinsonian monkey: a pilot study = 편측 파킨슨병 원숭이 모델은 경동맥 혈류속도의 비대칭성에 따라 손상영역이 달라질 수 있다

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dc.contributor.authorJincheol Seo-
dc.contributor.authorKyung Seob Lim-
dc.contributor.authorChang-Yeop Jeon-
dc.contributor.authorSeung Ho Baek-
dc.contributor.authorHyeon-Gu Yeo-
dc.contributor.authorWon Seok Choi-
dc.contributor.authorSung Hyun Park-
dc.contributor.authorKang Jin Jeong-
dc.contributor.authorJinyoung Won-
dc.contributor.authorKeonwoo Kim-
dc.contributor.authorJunghyung Park-
dc.contributor.authorJiyeon Cho-
dc.contributor.authorJung Bae Seong-
dc.contributor.authorMinji Kim-
dc.contributor.authorYu Gyeong Kim-
dc.contributor.authorJae Won Huh-
dc.contributor.authorS Kim-
dc.contributor.authorY H Lim-
dc.contributor.authorH W Park-
dc.contributor.authorH M Tak-
dc.contributor.authorM S Heo-
dc.contributor.authorJ W Choi-
dc.contributor.authorS H Paek-
dc.contributor.authorYoungjeon Lee-
dc.date.accessioned2022-11-11T16:32:23Z-
dc.date.available2022-11-11T16:32:23Z-
dc.date.issued2022-
dc.identifier.issn2090-8083-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/30579-
dc.description.abstractThe hemiparkinsonian nonhuman primate model induced by unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the carotid artery is used to study Parkinson’s disease. However, there have been no studies that the contralateral distribution of MPTP via the cerebral collateral circulation is provided by both the circle of Willis (CoW) and connections of the carotid artery. To investigate whether MPTP-induced unilaterally damaged regions were determined by asymmetrical cerebral blood 7ow, the di8erential asymmetric damage of striatal subregions, and examined structural asymmetries in a circle of Willis, and blood 7ow velocity of the common carotid artery were observed in three monkeys that were infused with MPTP through the left internal carotid artery. Lower 7ow velocity in the ipsilateral common carotid artery and a higher ratio of ipsilateral middle cerebral artery diameter to anterior cerebral artery diameter resulted in unilateral damage. Additionally, the unilateral damaged monkey observed the apomorphine-induced contralateral rotation behavior and the temporary increase of plasma RANTES. Contrastively, higher 7ow velocity in the ipsilateral common carotid artery was observed in the bilateral damaged monkey. It is suggested that asymmetry of blood 7ow velocity and structural asymmetry of the circle of Willis should be taken into consideration when establishing more e<cient hemiparkinsonian nonhuman primate models.-
dc.publisherHindawi-
dc.titleDetermination of the unilaterally damaged region may depend on the asymmetry of carotid blood flow velocity in hemiparkinsonian monkey: a pilot study = 편측 파킨슨병 원숭이 모델은 경동맥 혈류속도의 비대칭성에 따라 손상영역이 달라질 수 있다-
dc.title.alternativeDetermination of the unilaterally damaged region may depend on the asymmetry of carotid blood flow velocity in hemiparkinsonian monkey: a pilot study-
dc.typeArticle-
dc.citation.titleParkinsons Disease-
dc.citation.number0-
dc.citation.endPage4382145-
dc.citation.startPage4382145-
dc.citation.volume2022-
dc.contributor.affiliatedAuthorJincheol Seo-
dc.contributor.affiliatedAuthorKyung Seob Lim-
dc.contributor.affiliatedAuthorChang-Yeop Jeon-
dc.contributor.affiliatedAuthorSeung Ho Baek-
dc.contributor.affiliatedAuthorHyeon-Gu Yeo-
dc.contributor.affiliatedAuthorWon Seok Choi-
dc.contributor.affiliatedAuthorSung Hyun Park-
dc.contributor.affiliatedAuthorKang Jin Jeong-
dc.contributor.affiliatedAuthorJinyoung Won-
dc.contributor.affiliatedAuthorKeonwoo Kim-
dc.contributor.affiliatedAuthorJunghyung Park-
dc.contributor.affiliatedAuthorJiyeon Cho-
dc.contributor.affiliatedAuthorJung Bae Seong-
dc.contributor.affiliatedAuthorMinji Kim-
dc.contributor.affiliatedAuthorYu Gyeong Kim-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorYoungjeon Lee-
dc.contributor.alternativeName서진철-
dc.contributor.alternativeName임경섭-
dc.contributor.alternativeName전창엽-
dc.contributor.alternativeName백승호-
dc.contributor.alternativeName여현구-
dc.contributor.alternativeName최원석-
dc.contributor.alternativeName박성현-
dc.contributor.alternativeName정강진-
dc.contributor.alternativeName원진영-
dc.contributor.alternativeName김건우-
dc.contributor.alternativeName박정형-
dc.contributor.alternativeName조지연-
dc.contributor.alternativeName성중배-
dc.contributor.alternativeName김민지-
dc.contributor.alternativeName김유경-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName김삼환-
dc.contributor.alternativeName임용훈-
dc.contributor.alternativeName박형우-
dc.contributor.alternativeName탁혜민-
dc.contributor.alternativeName허만성-
dc.contributor.alternativeName최지웅-
dc.contributor.alternativeName백선하-
dc.contributor.alternativeName이영전-
dc.identifier.bibliographicCitationParkinsons Disease, vol. 2022, pp. 4382145-4382145-
dc.identifier.doi10.1155/2022/4382145-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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