Anti-itching and anti-inflammatory effects of kushenol F via the inhibition of TSLP production

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Anti-itching and anti-inflammatory effects of kushenol F via the inhibition of TSLP production
Seongyea Cho; E Y Gong; Wonbeak Yoo; Hyunji Choi; D Jung; Kyung Hee Noh; S Kim; S H Kim; Hyeong Kyu Lee
Bibliographic Citation
Pharmaceuticals, vol. 15, no. 11, pp. 1347-1347
Publication Year
Atopic dermatitis (AD) is a chronic inflammatory skin disease that results from eczema, itching, disrupted barrier function and aberrant cutaneous immune responses. The aim of the present study was to assess the efficacy of kushenol F as an effective treatment for AD via the suppression of thymic stromal lymphopoietin (TSLP) production. The results of the present study demonstrated that the clinical symptoms of AD were less severe and there was reduced ear thickening and scratching behavior in kushenol F-treated Dermatophagoides farinae extract (DFE)/1-chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD mice. Histopathological analysis demonstrated that kushenol F decreased the DFE/DNCB-induced infiltration of eosinophil and mast cells and TSLP protein expression levels. Furthermore, kushenol F-treated mice exhibited significantly lower concentrations of serum histamine, IgE and IgG2a compared with the DFE/DNCB-induced control mice. Kushenol F also significantly decreased phosphorylated NF-κB and IKK levels and the mRNA expression levels of IL-1β and IL-6 in cytokine combination-induced human keratinocytes. The results of the present study suggested that kushenol F may be a potential therapeutic candidate for the treatment of AD via reducing TSLP levels.
Kushenol FAtopic dermatitisThymic stromal lymphopoietin (TSLP)ItchingInflammation
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Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
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