The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages

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Title
The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages
Author(s)
D Park; G Lim; Sung Jin Yoon; H S Yi; D W Choi
Bibliographic Citation
BMB Reports, vol. 55, no. 11, pp. 519-527
Publication Year
2022
Abstract
Macrophage activation has long been implicated in a myriad of human pathophysiology, particularly in the context of the dysregulated capacities of an unleashing intracellular or/and extracellular inflammatory response. A growing number of studies have functionally coupled the macrophages’ inflammatory capacities with dynamic metabolic reprogramming which occurs during activation, albeit the results have been mostly interpreted through classic metabolism point of view; macrophages take advantage of the rewired metabolism as a source of energy and for biosynthetic precursors. However, a specific subset of metabolic products, namely immune-modulatory metabolites, has recently emerged as significant regulatory signals which control inflammatory responses in macrophages and the relevant extracellular milieu. In this review, we introduce recently highlighted immuno-modulatory metabolites, with the aim of understanding their physiological and pathological relevance in the macrophage inflammatory response.
Keyword
Immuno-modulatory metabolitesInflammatory diseasesMacrophages
ISSN
1976-6696
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5483/BMBRep.2022.55.11.128
Type
Article
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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