Cited 4 time in
- Title
- Specific upregulation of extracellular miR-6238 in particulate matter-induced acute lung injury and its immunomodulation
- Author(s)
- S Park; M Kim; Minkyung Park; Y Jin; Seon-Jin Lee; H Lee
- Bibliographic Citation
- Journal of Hazardous Materials, vol. 445, pp. 130466-130466
- Publication Year
- 2023
- Abstract
- Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening diseases characterized by a severe inflammatory response and the destruction of alveolar epithelium and endothelium. ALI/ARDS is caused by pathogens and toxic environmental stimuli, such as particulate matter (PM). However, the general symptoms of ALI/ARDS are similar, and determining the cause of lung injury is often challenging. In this study, we investigated whether there is a critical miRNA that characterizes PM-induced ALI. We found that the expression of miR-6238 is specifically upregulated in lung tissue and lung-derived extracellular vesicles (EVs) in response to PM exposure. Notably, bacterial endotoxin (Lipopolysaccharide; LPS or peptidoglycan; PTG) does not induce the expression of miR-6238 in the lung. Instead, the expression of miR-155 is dramatically increased in LPS-induced ALI. We further demonstrated that human lung epithelial cells and macrophages predominantly produce miR-6238 and miR-155, respectively. Mechanistically, EV-miR-6238 is effectively internalized into alveolar macrophages (AMs) and regulates inflammatory responses in vivo. CXCL3 is a main target of miR-6238 in AMs and modulates neutrophil infiltration into the lung alveoli. Collectively, our findings suggest that miR-6238 is a novel regulator of pulmonary inflammation and a putative biomarker that distinguishes PM-induced ALI from endotoxin (LPS/PTG)-mediated ALI.
- Keyword
- Extracellular vesiclesParticulate mattermiRNAAcute lung injuryAcute respiratory distress syndrome
- ISSN
- 0304-3894
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.jhazmat.2022.130466
- Type
- Article
- Appears in Collections:
- Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
- Files in This Item:
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