Methyl P-coumarate ameliorates the inflammatory response in activated-airway epithelial cells and mice with allergic asthma = Methyl P-coumarate의 항천식 효과

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Title
Methyl P-coumarate ameliorates the inflammatory response in activated-airway epithelial cells and mice with allergic asthma = Methyl P-coumarate의 항천식 효과
Author(s)
Ji Won Park; Jinseon Choi; Juhyun Lee; Jin-Mi Park; Seong Man Kim; J H Min; Da-Yun Seo; Soo Hyeon Goo; Ju-Hee Kim; Ok-Kyoung KwonKihoon LeeKyung Seop AhnSei-Ryang OhJae-Won Lee
Bibliographic Citation
International Journal of Molecular Sciences, vol. 23, no. 23, pp. 14909-14909
Publication Year
2022
Abstract
Methyl p-coumarate (methyl p-hydroxycinnamate) (MH) is a natural compound found in a variety of plants. In the present study, we evaluated the ameliorative effects of MH on airway inflammation in an experimental model of allergic asthma (AA). In this in vitro study, MH was found to exert anti-inflammatory activity on PMA-stimulated A549 airway epithelial cells by suppressing the secretion of IL-6, IL-8, MCP-1, and ICAM-1. In addition, MH exerted an inhibitory effect not only on NF-κB (p-NF-κB and p-IκB) and AP-1 (p-c-Fos and p-c-Jun) activation but also on A549 cell and EOL-1 cell (eosinophil cell lines) adhesion. In LPS-stimulated RAW264.7 macrophages, MH had an inhibitory effect on TNF-α, IL-1β, IL-6, and MCP-1. The results from in vivo study revealed that the increases in eosinophils/Th2 cytokines/MCP-1 in the bronchoalveolar lavage fluid (BALF) and IgE in the serum of OVA-induced mice with AA were effectively inhibited by MH administration. MH also exerted a reductive effect on the immune cell influx, mucus secretion, and iNOS/COX-2 expression in the lungs of mice with AA. The effects of MH were accompanied by the inactivation of NF-κB. Collectively, the findings of the present study indicated that MH attenuates airway inflammation in mice with AA, suggesting its potential as an adjuvant in asthma therapy.
Keyword
AsthmaMethyl p-coumarateTh2 cytokinesEosinophilNF-kB
ISSN
1661-6596
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms232314909
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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