DC Field | Value | Language |
---|---|---|
dc.contributor.author | Y Lee | - |
dc.contributor.author | J H Oh | - |
dc.contributor.author | N Li | - |
dc.contributor.author | Hyun-Jae Jang | - |
dc.contributor.author | Kyung Seop Ahn | - |
dc.contributor.author | Sei-Ryang Oh | - |
dc.contributor.author | D H Lee | - |
dc.contributor.author | J H Chung | - |
dc.date.accessioned | 2023-01-09T16:32:50Z | - |
dc.date.available | 2023-01-09T16:32:50Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/30883 | - |
dc.description.abstract | Skullcapflavone II (SFII), a flavonoid derived from Scutellaria baicalensis, is an anticancer agent. We aimed to validate SFII for atopic dermatitis (AD) therapy by demonstrating the anti-inflammatory effects of SFII in an AD mouse model produced by the topical application of the vitamin D3 analog MC903. We showed that topical treatment with SFII significantly suppressed MC903-induced serum IgE levels compared with topical hydrocortisone (HC) treatment. Topical SFII also prevents MC903-induced pruritus, skin hyperplasia, and inflammatory immune cell infiltration into lesional skin comparable to topical HC. In addition, MC903-induced immune cell chemoattractants and AD-associated cytokine production in skin lesions were effectively suppressed by topical SFII. The production of MC903-induced effector cytokines influencing T helper (Th)2 and Th17 polarization in lesioned skin is significantly inhibited by topical SFII. Furthermore, we showed that SFII can directly inhibit the production of AD-associated cytokines by human primary keratinocytes, mouse bone marrow-derived cells (BMDCs), and mouse CD4+ T cells in vitro. Lastly, we demonstrated that topical SFII more effectively suppressed serum IgE levels, the production of IL-4 and thymic stromal lymphopoietin (TSLP), and infiltration of CD4+ T cells and Gr-1+ cells (neutrophils) into lesion skin compared to topical baicalein (a flavonoid derived from Scutellaria baicalensis), which has anti-inflammatory effects. Taken together, our findings suggest that SFII may have promising therapeutic potential for this complex disease via the regulation of multiple AD-associated targets. | - |
dc.publisher | Frontiers Media Sa | - |
dc.title | Topical Skullcapflavone II attenuates atopic dermatitis in a mouse model by directly inhibiting associated cytokines in different cell types | - |
dc.title.alternative | Topical Skullcapflavone II attenuates atopic dermatitis in a mouse model by directly inhibiting associated cytokines in different cell types | - |
dc.type | Article | - |
dc.citation.title | Frontiers in Immunology | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 1064515 | - |
dc.citation.startPage | 1064515 | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Hyun-Jae Jang | - |
dc.contributor.affiliatedAuthor | Kyung Seop Ahn | - |
dc.contributor.affiliatedAuthor | Sei-Ryang Oh | - |
dc.contributor.alternativeName | 이영애 | - |
dc.contributor.alternativeName | 오장희 | - |
dc.contributor.alternativeName | Li | - |
dc.contributor.alternativeName | 장현재 | - |
dc.contributor.alternativeName | 안경섭 | - |
dc.contributor.alternativeName | 오세량 | - |
dc.contributor.alternativeName | 이동훈 | - |
dc.contributor.alternativeName | 정진호 | - |
dc.identifier.bibliographicCitation | Frontiers in Immunology, vol. 13, pp. 1064515-1064515 | - |
dc.identifier.doi | 10.3389/fimmu.2022.1064515 | - |
dc.subject.keyword | Skullcapflavone II | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | Pruritus | - |
dc.subject.keyword | Th2 cytokines | - |
dc.subject.keyword | IgE | - |
dc.subject.local | Skullcapflavone II | - |
dc.subject.local | Atopic Dermatitis | - |
dc.subject.local | Atopic dermatitis | - |
dc.subject.local | atopic dermatitis | - |
dc.subject.local | atopic dermatitis (AD) | - |
dc.subject.local | Atopic dermatitis (AD) | - |
dc.subject.local | Pruritus | - |
dc.subject.local | pruritus | - |
dc.subject.local | Th2 cytokines | - |
dc.subject.local | IgE | - |
dc.description.journalClass | Y | - |
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