Topical Skullcapflavone II attenuates atopic dermatitis in a mouse model by directly inhibiting associated cytokines in different cell types

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dc.contributor.authorY Lee-
dc.contributor.authorJ H Oh-
dc.contributor.authorN Li-
dc.contributor.authorHyun-Jae Jang-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorD H Lee-
dc.contributor.authorJ H Chung-
dc.date.accessioned2023-01-09T16:32:50Z-
dc.date.available2023-01-09T16:32:50Z-
dc.date.issued2022-
dc.identifier.issn1664-3224-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/30883-
dc.description.abstractSkullcapflavone II (SFII), a flavonoid derived from Scutellaria baicalensis, is an anticancer agent. We aimed to validate SFII for atopic dermatitis (AD) therapy by demonstrating the anti-inflammatory effects of SFII in an AD mouse model produced by the topical application of the vitamin D3 analog MC903. We showed that topical treatment with SFII significantly suppressed MC903-induced serum IgE levels compared with topical hydrocortisone (HC) treatment. Topical SFII also prevents MC903-induced pruritus, skin hyperplasia, and inflammatory immune cell infiltration into lesional skin comparable to topical HC. In addition, MC903-induced immune cell chemoattractants and AD-associated cytokine production in skin lesions were effectively suppressed by topical SFII. The production of MC903-induced effector cytokines influencing T helper (Th)2 and Th17 polarization in lesioned skin is significantly inhibited by topical SFII. Furthermore, we showed that SFII can directly inhibit the production of AD-associated cytokines by human primary keratinocytes, mouse bone marrow-derived cells (BMDCs), and mouse CD4+ T cells in vitro. Lastly, we demonstrated that topical SFII more effectively suppressed serum IgE levels, the production of IL-4 and thymic stromal lymphopoietin (TSLP), and infiltration of CD4+ T cells and Gr-1+ cells (neutrophils) into lesion skin compared to topical baicalein (a flavonoid derived from Scutellaria baicalensis), which has anti-inflammatory effects. Taken together, our findings suggest that SFII may have promising therapeutic potential for this complex disease via the regulation of multiple AD-associated targets.-
dc.publisherFrontiers Media Sa-
dc.titleTopical Skullcapflavone II attenuates atopic dermatitis in a mouse model by directly inhibiting associated cytokines in different cell types-
dc.title.alternativeTopical Skullcapflavone II attenuates atopic dermatitis in a mouse model by directly inhibiting associated cytokines in different cell types-
dc.typeArticle-
dc.citation.titleFrontiers in Immunology-
dc.citation.number0-
dc.citation.endPage1064515-
dc.citation.startPage1064515-
dc.citation.volume13-
dc.contributor.affiliatedAuthorHyun-Jae Jang-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.alternativeName이영애-
dc.contributor.alternativeName오장희-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeName장현재-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이동훈-
dc.contributor.alternativeName정진호-
dc.identifier.bibliographicCitationFrontiers in Immunology, vol. 13, pp. 1064515-1064515-
dc.identifier.doi10.3389/fimmu.2022.1064515-
dc.subject.keywordSkullcapflavone II-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordPruritus-
dc.subject.keywordTh2 cytokines-
dc.subject.keywordIgE-
dc.subject.localSkullcapflavone II-
dc.subject.localAtopic Dermatitis-
dc.subject.localAtopic dermatitis-
dc.subject.localatopic dermatitis-
dc.subject.localatopic dermatitis (AD)-
dc.subject.localAtopic dermatitis (AD)-
dc.subject.localPruritus-
dc.subject.localpruritus-
dc.subject.localTh2 cytokines-
dc.subject.localIgE-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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