Effects of Vigna angularis extract and its active compound hemiphloin against atopic dermatitis-like skin inflammation

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dc.contributor.authorSeon Gyeong Bak-
dc.contributor.authorHyung Jin Lim-
dc.contributor.authorEun Jae Park-
dc.contributor.authorYeong Seon Won-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorSoyoung Lee-
dc.contributor.authorS I Park-
dc.contributor.authorSeung Jae Lee-
dc.contributor.authorMun Chual Rho-
dc.date.accessioned2023-01-31T16:32:48Z-
dc.date.available2023-01-31T16:32:48Z-
dc.date.issued2023-
dc.identifier.issn2405-8440-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/30962-
dc.description.abstractVigna angularis is an edible crop and herbal medicine that is known to have antipyretic, anti-inflammatory, and anti-edema effects. Many studies have been conducted on the 95% ethanol extract of V. angularis, but there is little research on the 70% ethanol extract and hemiphloin, which is a new indicator component of the 70% ethanol extract of V. angularis. To investigate the in vitro anti-atopic effect and verify the mechanism action of 70% ethanol extract of V. angularis (VAE), TNF-α/IFN-γ-induced HaCaT keratinocytes were used. The VAE treatment alleviated TNF-α/IFN-γ-induced IL-1β, IL-6, IL-8, CCL17/TARC, and CCL22/MDC gene expressions and productions. VAE also inhibited the phosphorylation of MAPKs, including p38, ERK, JNK, STAT1, and NF-κB in TNF-α/IFN-γ-induced HaCaT cells. 2,4-dinitochlorobenzene (DNCB)-induced skin inflammation mice model, and HaCaT keratinocytes were used. In the DNCB-induced mouse model, VAE treatment alleviated ear thicknesses and IgE levels. Furthermore, VAE decreased IL-1β, IL-6, IL-8, CCL17/TARC, and CCL22/MDC gene expressions of DNCB-applied ear tissue. Additionally, we investigated the anti-atopic and anti-inflammatory effects of hemiphloin using TNF-α/IFN-γ-induced HaCaT keratinocytes and LPS-induced J774 macrophages. Treatment hemiphloin decreased gene expressions and productions of IL-1β, IL-6, IL-8, CCL17/TARC, and CCL22/MDC in TNF-α/IFN-γ-induced HaCaT cells. The phosphorylations of p38, ERK, STAT1, and NF-κB were inhibited by hemiphloin in TNF-α/IFN-γ-induced HaCaT cells. Finally, hemiphloin showed anti-inflammatory activities in LPS-induced J774 cells. It decreased LPS-induced NO productions and iNOS and COX-2 expressions. Treatment of hemiphloin also inhibited LPS-induced TNF-α, IL-1β, and IL-6 gene expressions. These results suggest that VAE is an anti-inflammatory agent for inflammatory skin diseases and that hemiphloin could be a therapeutic candidate for inflammatory skin diseases.-
dc.publisherElsevier-Cell Press-
dc.titleEffects of Vigna angularis extract and its active compound hemiphloin against atopic dermatitis-like skin inflammation-
dc.title.alternativeEffects of Vigna angularis extract and its active compound hemiphloin against atopic dermatitis-like skin inflammation-
dc.typeArticle-
dc.citation.titleHeliyon-
dc.citation.number2-
dc.citation.endPagee12994-
dc.citation.startPagee12994-
dc.citation.volume9-
dc.contributor.affiliatedAuthorSeon Gyeong Bak-
dc.contributor.affiliatedAuthorHyung Jin Lim-
dc.contributor.affiliatedAuthorEun Jae Park-
dc.contributor.affiliatedAuthorYeong Seon Won-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorSoyoung Lee-
dc.contributor.affiliatedAuthorSeung Jae Lee-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName박선경-
dc.contributor.alternativeName임형진-
dc.contributor.alternativeName박은재-
dc.contributor.alternativeName원영선-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName이소영-
dc.contributor.alternativeName박상익-
dc.contributor.alternativeName이승재-
dc.contributor.alternativeName노문철-
dc.identifier.bibliographicCitationHeliyon, vol. 9, no. 2, pp. e12994-e12994-
dc.identifier.doi10.1016/j.heliyon.2023.e12994-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordSkin inflammation-
dc.subject.keywordVigna angularis-
dc.subject.keywordHemiphloin-
dc.subject.localAtopic Dermatitis-
dc.subject.localAtopic dermatitis-
dc.subject.localatopic dermatitis-
dc.subject.localatopic dermatitis (AD)-
dc.subject.localAtopic dermatitis (AD)-
dc.subject.localSkin inflammation-
dc.subject.localskin inflammation-
dc.subject.localvigna angularis-
dc.subject.localVigna angularis-
dc.subject.localHemiphloin-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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