Cinnamomum verum extract inhibits NOX2/ROS and PKCδ/JNK/AP-1/NF-κB pathway-mediated inflammatory response in PMA-stimulated THP-1 monocytes

Cited 7 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorN Y Kim-
dc.contributor.authorS Kim-
dc.contributor.authorH M Park-
dc.contributor.authorC M Lim-
dc.contributor.authorJ Kim-
dc.contributor.authorJ Y Park-
dc.contributor.authorK B Jeon-
dc.contributor.authorA Poudel-
dc.contributor.authorH P Lee-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorJongmin Ahn-
dc.contributor.authorD Y Yoon-
dc.date.accessioned2023-02-09T16:33:23Z-
dc.date.available2023-02-09T16:33:23Z-
dc.date.issued2023-
dc.identifier.issn0944-7113-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/31003-
dc.description.abstractBackground: Cinnamomum verum J. Presl (Cinnamon) is widely used in the food and pharmaceutical industries. C. verum exhibits various biological activities. However, it is unclear whether C. verum can inhibit NOX, a major source of ROS generation, and exert anti-inflammatory and antioxidant effects in PMA-stimulated THP-1 cells. Purpose: This study investigates the anti-inflammatory and antioxidant effects of C. verum in PMA-stimulated THP-1 cells. Methods: The MeOH extract of C. verum was analyzed using UPLC-QTOF/MS. Anti-inflammatory and antioxidant effects of C. verum extract were examined by DCF-DA staining, immunofluorescence staining, RT-PCR, and immunoblotting in PMA-stimulated THP-1 cells. Results: C. verum and its components, cinnamic acid and coumarin, significantly attenuated the expression of IL-1β, IL-8, CCL5, and COX-2 in PMA-stimulated THP-1. C. verum decreased ROS levels via NOX2 downregulation, as well as ameliorated plasma membrane translocation of PKCδ and decreased JNK phosphorylation. Besides, C. verum suppressed the nuclear translocation of AP-1 and NF-κB, which modulates diverse pro-inflammatory genes. Conclusion: C. verum effectively inhibits inflammation and oxidative stress during monocyte-macrophage differentiation and downregulates inflammatory mediators via NOX2/ROS and PKCδ/JNK/AP-1/NF-κB signaling.-
dc.publisherElsevier-
dc.titleCinnamomum verum extract inhibits NOX2/ROS and PKCδ/JNK/AP-1/NF-κB pathway-mediated inflammatory response in PMA-stimulated THP-1 monocytes-
dc.title.alternativeCinnamomum verum extract inhibits NOX2/ROS and PKCδ/JNK/AP-1/NF-κB pathway-mediated inflammatory response in PMA-stimulated THP-1 monocytes-
dc.typeArticle-
dc.citation.titlePhytomedicine-
dc.citation.number0-
dc.citation.endPage154685-
dc.citation.startPage154685-
dc.citation.volume112-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorJongmin Ahn-
dc.contributor.alternativeName김나연-
dc.contributor.alternativeName김선화-
dc.contributor.alternativeName박효민-
dc.contributor.alternativeName임채민-
dc.contributor.alternativeName김진주-
dc.contributor.alternativeName박재영-
dc.contributor.alternativeName전경배-
dc.contributor.alternativeNamePoudel-
dc.contributor.alternativeName이희봄-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName안종민-
dc.contributor.alternativeName윤도영-
dc.identifier.bibliographicCitationPhytomedicine, vol. 112, pp. 154685-154685-
dc.identifier.doi10.1016/j.phymed.2023.154685-
dc.subject.keywordCinnamomum verum-
dc.subject.keywordCinnamon-
dc.subject.keywordAnti-inflammation-
dc.subject.keywordAntioxidant-
dc.subject.keywordCinnamic acid-
dc.subject.keywordCoumarin-
dc.subject.localCinnamomum verum-
dc.subject.localCinnamon-
dc.subject.localAnti-inflammation-
dc.subject.localAntiinflammation-
dc.subject.localanti-inflammation-
dc.subject.localAnti-Inflammation-
dc.subject.localantiinflammation-
dc.subject.localAnti-oxidant-
dc.subject.localAntioxidant-
dc.subject.localAntioxidants-
dc.subject.localANTIOXIDANT-
dc.subject.localanti-oxidants-
dc.subject.localantioxidant-
dc.subject.localantioxidants-
dc.subject.localCinnamic acid-
dc.subject.localcinnamic acid-
dc.subject.localCoumarin-
dc.subject.localCoumarins-
dc.subject.localcoumarin-
dc.subject.localcoumarins-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.