DC Field | Value | Language |
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dc.contributor.author | N Y Kim | - |
dc.contributor.author | S Kim | - |
dc.contributor.author | H M Park | - |
dc.contributor.author | C M Lim | - |
dc.contributor.author | J Kim | - |
dc.contributor.author | J Y Park | - |
dc.contributor.author | K B Jeon | - |
dc.contributor.author | A Poudel | - |
dc.contributor.author | H P Lee | - |
dc.contributor.author | Sei-Ryang Oh | - |
dc.contributor.author | Jongmin Ahn | - |
dc.contributor.author | D Y Yoon | - |
dc.date.accessioned | 2023-02-09T16:33:23Z | - |
dc.date.available | 2023-02-09T16:33:23Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 0944-7113 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/31003 | - |
dc.description.abstract | Background: Cinnamomum verum J. Presl (Cinnamon) is widely used in the food and pharmaceutical industries. C. verum exhibits various biological activities. However, it is unclear whether C. verum can inhibit NOX, a major source of ROS generation, and exert anti-inflammatory and antioxidant effects in PMA-stimulated THP-1 cells. Purpose: This study investigates the anti-inflammatory and antioxidant effects of C. verum in PMA-stimulated THP-1 cells. Methods: The MeOH extract of C. verum was analyzed using UPLC-QTOF/MS. Anti-inflammatory and antioxidant effects of C. verum extract were examined by DCF-DA staining, immunofluorescence staining, RT-PCR, and immunoblotting in PMA-stimulated THP-1 cells. Results: C. verum and its components, cinnamic acid and coumarin, significantly attenuated the expression of IL-1β, IL-8, CCL5, and COX-2 in PMA-stimulated THP-1. C. verum decreased ROS levels via NOX2 downregulation, as well as ameliorated plasma membrane translocation of PKCδ and decreased JNK phosphorylation. Besides, C. verum suppressed the nuclear translocation of AP-1 and NF-κB, which modulates diverse pro-inflammatory genes. Conclusion: C. verum effectively inhibits inflammation and oxidative stress during monocyte-macrophage differentiation and downregulates inflammatory mediators via NOX2/ROS and PKCδ/JNK/AP-1/NF-κB signaling. | - |
dc.publisher | Elsevier | - |
dc.title | Cinnamomum verum extract inhibits NOX2/ROS and PKCδ/JNK/AP-1/NF-κB pathway-mediated inflammatory response in PMA-stimulated THP-1 monocytes | - |
dc.title.alternative | Cinnamomum verum extract inhibits NOX2/ROS and PKCδ/JNK/AP-1/NF-κB pathway-mediated inflammatory response in PMA-stimulated THP-1 monocytes | - |
dc.type | Article | - |
dc.citation.title | Phytomedicine | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 154685 | - |
dc.citation.startPage | 154685 | - |
dc.citation.volume | 112 | - |
dc.contributor.affiliatedAuthor | Sei-Ryang Oh | - |
dc.contributor.affiliatedAuthor | Jongmin Ahn | - |
dc.contributor.alternativeName | 김나연 | - |
dc.contributor.alternativeName | 김선화 | - |
dc.contributor.alternativeName | 박효민 | - |
dc.contributor.alternativeName | 임채민 | - |
dc.contributor.alternativeName | 김진주 | - |
dc.contributor.alternativeName | 박재영 | - |
dc.contributor.alternativeName | 전경배 | - |
dc.contributor.alternativeName | Poudel | - |
dc.contributor.alternativeName | 이희봄 | - |
dc.contributor.alternativeName | 오세량 | - |
dc.contributor.alternativeName | 안종민 | - |
dc.contributor.alternativeName | 윤도영 | - |
dc.identifier.bibliographicCitation | Phytomedicine, vol. 112, pp. 154685-154685 | - |
dc.identifier.doi | 10.1016/j.phymed.2023.154685 | - |
dc.subject.keyword | Cinnamomum verum | - |
dc.subject.keyword | Cinnamon | - |
dc.subject.keyword | Anti-inflammation | - |
dc.subject.keyword | Antioxidant | - |
dc.subject.keyword | Cinnamic acid | - |
dc.subject.keyword | Coumarin | - |
dc.subject.local | Cinnamomum verum | - |
dc.subject.local | Cinnamon | - |
dc.subject.local | Anti-inflammation | - |
dc.subject.local | Antiinflammation | - |
dc.subject.local | anti-inflammation | - |
dc.subject.local | Anti-Inflammation | - |
dc.subject.local | antiinflammation | - |
dc.subject.local | Anti-oxidant | - |
dc.subject.local | Antioxidant | - |
dc.subject.local | Antioxidants | - |
dc.subject.local | ANTIOXIDANT | - |
dc.subject.local | anti-oxidants | - |
dc.subject.local | antioxidant | - |
dc.subject.local | antioxidants | - |
dc.subject.local | Cinnamic acid | - |
dc.subject.local | cinnamic acid | - |
dc.subject.local | Coumarin | - |
dc.subject.local | Coumarins | - |
dc.subject.local | coumarin | - |
dc.subject.local | coumarins | - |
dc.description.journalClass | Y | - |
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