Effect of single amino acid substitutions on the thermal unfolding of P22 tailspike protein

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Title
Effect of single amino acid substitutions on the thermal unfolding of P22 tailspike protein
Author(s)
Sang Chul Lee; Myeong Hee Yu
Bibliographic Citation
Molecules and Cells, vol. 1, no. 3, pp. 267-271
Publication Year
1991
Abstract
We examined the thermal unfolding of four different mutant tailspike proteins of phage P22, which fold and mature more efficiently than the wild type. The mutations did not affect the unfolding of native protein to the intermediate conformation, but did affect the unfolding of intermediate to fully denatured monomer. For three mutations this process was more rapid than that for the wild type. The results suggest that the mutations which increa狀 the efficiency of folding and maturation of the tailspike in vivo do not necessarily decrease the thermal unfolding process of the native proteins in vitro.
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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