Interaction between polyalbumin and pre-S2 region of hepatitis B surface antigen does not require the whole native structure of human serum albumin

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Title
Interaction between polyalbumin and pre-S2 region of hepatitis B surface antigen does not require the whole native structure of human serum albumin
Author(s)
Hye Young Yun; Hye Young Kweon; Myung Kyu Lee; Kil Lyong Kim; Kyung Soo Hahm
Bibliographic Citation
Molecules and Cells, vol. 1, no. 4, pp. 397-401
Publication Year
1991
Abstract
Human serum albumin was treated with glutaraldehyde and the modified products were separated by size into three species: monomer, dimer and polymer. All the species produced from native human serum albumin bound to pre-S2 region (120-174) of hepatitis B virus surface antigen. The same was true of three modified species which were derived from the denatured human serum albumin. Receptor-ligand immunoblotting of human serum albumin cleaved by cyanogen bromide and fixed by glutaraldehyde indicated that binding of pre-S2 to polyalbumin could be confined to at least three segments (amino acids 124-297, 329-445 and 446-547) of human serum albumin.
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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