Production of biologically active human recombinant interleukin-1βin E. coli = 생리활성능을 지닌 사람 인터루킨-1β재조합 단백질의 대장균내 생산

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Title
Production of biologically active human recombinant interleukin-1βin E. coli = 생리활성능을 지닌 사람 인터루킨-1β재조합 단백질의 대장균내 생산
Author(s)
Sue Nie Park; Hankil Park; Doe Sun Na; In Seong Choe; Tai Wha Chung
Bibliographic Citation
Korean Biochemical Journal, vol. 24, no. 3, pp. 215-223
Publication Year
1991
Abstract
We produced human recombinant interleukin-ip in E. coll to study the mechanism (s) of its pleiotropic action(s), and to develop it as an anti-cancer or anti-inflammatory drug. We constructed expression vectors using lambda PL promoter. Expression of hrIL-ip in E. coli was induced and the production of the protein was confirmed by Western blot assay. We also confirmed the presence of biological activity of recombinant IL-lg protein by demonstrating its growth promoting effect on mouse thymocytes.
ISSN
0368-4881
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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