Single cell analysis of human thyroid reveals the transcriptional signatures of aging

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Single cell analysis of human thyroid reveals the transcriptional signatures of aging
Y Hong; H J Kim; S Park; S Yi; M A Lim; S E Lee; J W Chang; H R Won; J R Kim; H Ko; Seon-Young KimSeon-Kyu KimJong Lyul ParkIn-Sun Chu; J M Kim; K H Kim; J H Lee; Y S Ju; M Shong; B S Koo; W Y Park; Y E Kang
Bibliographic Citation
Endocrinology, vol. 164, no. 4, pp. bqad029-bqad029
Publication Year
The thyroid gland plays a critical role in the maintenance of whole-body metabolism. However, aging frequently impairs homeostatic maintenance by thyroid hormones due to increased prevalence of subclinical hypothyroidism associated with mitochondrial dysfunction, inflammation, and fibrosis. To understand the specific aging-related changes of endocrine function in thyroid epithelial cells, we performed single-cell RNA sequencing (RNA-seq) of 54 726 cells derived from pathologically normal thyroid tissues from 7 patients who underwent thyroidectomy. Thyroid endocrine epithelial cells were clustered into 5 distinct subpopulations, and a subset of cells was found to be particularly vulnerable with aging, showing functional deterioration associated with the expression of metallothionein (MT) and major histocompatibility complex class II genes. We further validated that increased expression of MT family genes are highly correlated with thyroid gland aging in bulk RNAseq datasets. This study provides evidence that aging induces specific transcriptomic changes across multiple cell populations in the human thyroid gland.
ThyroidAgingSingle-cell RNA sequencingMetallothioneinFibrosis
Endocrine Soc
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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