Antioxidants prevent particulate matter-induced senescence of lung fibroblasts

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Antioxidants prevent particulate matter-induced senescence of lung fibroblasts
Sein Jin; Sung Jin Yoon; Na-Young Jung; Wang Sik Lee; Jinyoung JeongYoung-Jun Park; W Kim; Doo-Byoung OhJinho Seo
Bibliographic Citation
Heliyon, vol. 9, no. 3, pp. e14179-e14179
Publication Year
Particulate matter (PM) contributes to human diseases, particularly lung disease; however, the molecular mechanism of its action is yet to be determined. Herein, we found that prolonged PM exposure induced the cellular senescence of normal lung fibroblasts via a DNA damage-mediated response. This PM-induced senescence (PM-IS) was only observed in lung fibroblasts but not in A549 lung adenocarcinoma cells. Mechanistic analysis revealed that reactive oxygen species (ROS) activate the DNA damage response signaling axis, increasing p53 phosphorylation, ultimately leading to cellular senescence via an increase in p21 expression without affecting the p16-pRB pathway. A549 cells, instead, were resistant to PM-IS due to the PM-induced ROS production suppression. Water-soluble antioxidants, such as vitamin C and N-Acetyl Cysteine, were found to alleviate PM-IS by suppressing ROS production, implying that antioxidants are a promising therapeutic intervention for PM-mediated lung pathogenesis.
Particulate matterCellular senescenceReactive oxygen speciesDNA damage ResponseAntioxidants
Elsevier-Cell Press
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Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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