IL-17A and Th17 cells contribute to endometrial cell survival by inhibiting apoptosis and NK cell mediated cytotoxicity of endometrial cells via ERK1/2 pathway
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- Title
- IL-17A and Th17 cells contribute to endometrial cell survival by inhibiting apoptosis and NK cell mediated cytotoxicity of endometrial cells via ERK1/2 pathway
- Author(s)
- Young-Ju Kang; Hee Jun Cho; Yunhee Lee; Arum Park; Mi Jeong Kim; I C Jeung; Y W Jung; Haiyoung Jung; In Pyo Choi; Hee Gu Lee; Suk Ran Yoon
- Bibliographic Citation
- Immune Network, vol. 23, no. 2, pp. e14-e14
- Publication Year
- 2023
- Abstract
- Immune status including the immune cells and cytokine profiles has been implicated in the development of endometriosis. In this study, we analyzed Th17 cells and IL-17A in peritoneal fluid (PF) and endometrial tissues of patients with (n=10) and without (n=26) endometriosis. Our study has shown increased Th17 cell population and IL-17A level in PF with endometriosis patients. To determine the roles of IL-17A and Th17 cells in the development of endometriosis, the effect of IL-17A, major cytokine of Th17, on endometrial cells isolated from endometriotic tissues was examined. Recombinant IL-17A promoted survival of endometrial cells accompanied by increased expression of anti-apoptotic genes, including Bcl-2 and MCL1, and the activation of ERK1/2 signaling. In addition, treatment of IL-17A to endometrial cells inhibited NK cell mediated cytotoxicity and induced HLA-G expression on endometrial cells. IL-17A also promoted migration of endometrial cells. Our data suggest that Th17 cells and IL-17A play critical roles in the development of endometriosis by promoting endometrial cell survival and conferring a resistance to NK cell cytotoxicity through the activation of ERK1/2 signaling. Targeting IL-17A has potential as a new strategy for the treatment of endometriosis.
- Keyword
- IL-17ATh17 cellsEndometriosisApoptosisNK cell cytotoxicityERK
- ISSN
- 1598-2629
- Publisher
- Korea Soc-Assoc-Inst
- DOI
- http://dx.doi.org/10.4110/in.2023.23.e14
- Type
- Article
- Appears in Collections:
- Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
- Files in This Item:
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