Recent advancements in technologies to detect enterohaemorrhagic Escherichia coli Shiga toxins

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dc.contributor.authorJ Kim-
dc.contributor.authorJ B Lee-
dc.contributor.authorJ Park-
dc.contributor.authorC Koo-
dc.contributor.authorMoo-Seung Lee-
dc.date.accessioned2023-05-24T16:33:48Z-
dc.date.available2023-05-24T16:33:48Z-
dc.date.issued2023-
dc.identifier.issn1017-7825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/31774-
dc.description.abstractShiga toxin (Stxs)-producing enterohaemorrhagic Escherichia coli (EHEC) and Shigella dysenteriae serotype 1 are major causative agents of severe bloody diarrhea (known as hemorrhagic colitis) and hemolytic uremic syndrome (HUS) associated with extraintestinal complications such as acute renal failure and neurologic impairment in infected patients under 9 years of age. Extreme nephrotoxicity of Stxs in HUS patients is associated with severe outcomes, highlighting the need to develop technologies to detect low levels of the toxin in environmental or food samples. Currently, the conventional polymerase chain reaction (PCR) or immunoassay is the most broadly used assay to detect the toxin. However, these assays are laborious, time-consuming, and costly. More recently, numerous studies have described novel, highly sensitive, and portable methods for detecting Stxs from EHEC. To contextualize newly emerging Stxs detection methods, we briefly explain the basic principles of these methods, including lateral flow assays, optical detection, and electrical detection. We subsequently describe existing and newly emerging rapid detection technologies to identify and measure Stxs.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleRecent advancements in technologies to detect enterohaemorrhagic Escherichia coli Shiga toxins-
dc.title.alternativeRecent advancements in technologies to detect enterohaemorrhagic Escherichia coli Shiga toxins-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number5-
dc.citation.endPage573-
dc.citation.startPage559-
dc.citation.volume33-
dc.contributor.affiliatedAuthorMoo-Seung Lee-
dc.contributor.alternativeName김정태-
dc.contributor.alternativeName이준봉-
dc.contributor.alternativeName박재원-
dc.contributor.alternativeName구치완-
dc.contributor.alternativeName이무승-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 33, no. 5, pp. 559-573-
dc.identifier.doi10.4014/jmb.2212.12025-
dc.subject.keywordShiga toxins-
dc.subject.keywordEHEC Stxs-
dc.subject.keywordHemolytic uremic syndrome-
dc.subject.keywordSensor-
dc.subject.keywordDevice-
dc.subject.localShiga toxin-
dc.subject.localShiga toxins-
dc.subject.localShiga Toxin-
dc.subject.localHemolytic uremic syndrome-
dc.subject.localhemolytic uremic syndrome-
dc.subject.localhemolytic uremic syndrome-
dc.subject.localHemolytic uremic syndrome (HUS)-
dc.subject.localHemolytic Uremic Syndrome (HUS)-
dc.subject.localHemolytic Uremic Syndrome-
dc.subject.localsensor-
dc.subject.localsensors-
dc.subject.localSensor-
dc.subject.localSensors-
dc.subject.localDevice-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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