Differentiation of human B lymphocytes by B cell stimulating cytokines = B세포 자극 cytokine들에 의한 human B 림프구의 분화효과

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dc.contributor.authorWoo-Jin Na-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorIn Pyo Choi-
dc.contributor.authorKwang Ho Pyun-
dc.date.accessioned2017-04-19T08:44:09Z-
dc.date.available2017-04-19T08:44:09Z-
dc.date.issued1992-
dc.identifier.issnI000-0015-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/3190-
dc.description.abstractTo investigate the effects of IL-2, IL-4 and IL-6 on the proliferation and differentiation of human B lymphocytes, the production of Ig classes & IgG subclasses, IL-2 & IL~6 receptors expression and Ig isotype switch were examined using highly purified tonsilar B lymphocytes divided into four developmental stages : small resting B lymphocytes, large B lymphocytes, SAC-blast B lym-phocytes and mature B lymphocytes. IL-2 was found as major cytokine inducing Ig production from SAC-blast B lymphocytes, on which IL-2 receptors were highly expressed. IL-4 showed some effects on ig production, which might be from the IL-4 induced B lymphocytes proliferation, but did not show any evidence of Ig class switch as seen in murine system‘ IL-6 induced remarkable Ig production from mature B lymphocytes at the final stage of differentiation^ on which IL-6 receptors were highly expressed. The synergistic effects on Ig production by combining treatment of IL~2 and IL-4, or IL-2 and IL-6 were observed from SAC-blast B lymphocytes, but not from the combination of IL-4 and IL-6. Ig class switch from IgM to IgG and IgA and IgG subclass switch from IgG3 to IgGl,IgG2 and IgG4 were observed with the progression of B lymphocytes differentiation. These results suggest that IL-2 and IL-6 appear to be major factors of B lymphocytes different tiation and Ig isotype are switched in the downstream order of Ig heavy chain constant region genes with the progression of B lymphocytes differentiation-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleDifferentiation of human B lymphocytes by B cell stimulating cytokines = B세포 자극 cytokine들에 의한 human B 림프구의 분화효과-
dc.title.alternativeDifferentiation of human B lymphocytes by B cell stimulating cytokines-
dc.typeArticle-
dc.citation.titleKorean Journal of Immunology-
dc.citation.number1-
dc.citation.endPage96-
dc.citation.startPage85-
dc.citation.volume14-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.affiliatedAuthorKwang Ho Pyun-
dc.contributor.alternativeName나우진-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName최인표-
dc.contributor.alternativeName변광호-
dc.identifier.bibliographicCitationKorean Journal of Immunology, vol. 14, no. 1, pp. 85-96-
dc.description.journalClassN-
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Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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