Enzymatic preparation of optically active 2-acetoxymethylglycidol, a new chiral building block in natural product synthesis

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Title
Enzymatic preparation of optically active 2-acetoxymethylglycidol, a new chiral building block in natural product synthesis
Author(s)
Young Bae Seu; Yung Hee Kho
Bibliographic Citation
Tetrahedron Letters, vol. 33, no. 46, pp. 7015-7016
Publication Year
1992
Abstract
Asymmetric hydrolysis of geminally disubstituted achiral diacetate 2 with lipase PPL yielded optically active (R)-(-)-2-acetoxymethylglycidol 3 and its reduction gave compound 6, useful as the tert-alcohol chiral building block.
ISSN
0040-4039
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0040-4039(00)60920-6
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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