Infertility of transgenic mice expressing human growth hormone gene = 사람 성장호르몬 유전자를 발현하는 형질전환생쥐의 불임성

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Title
Infertility of transgenic mice expressing human growth hormone gene = 사람 성장호르몬 유전자를 발현하는 형질전환생쥐의 불임성
Author(s)
Yong Mahn Han; Man Jong Kang; Chul Sang Lee; Dae Yeul Yu; Kyung Kwang Lee
Bibliographic Citation
Reproductive & Developmental Biology, vol. 16, no. 3, pp. 225-230
Publication Year
1992
Abstract
Many transgenic mice expressing human growth hormone gene were infertile. To investigate the infertility of these transgenic mice, it was looked into the estrus cycle and sexual behaviour and also tested through in vitro fertilization whether the germ cells of these mice were normal or 'not. The infertile female transgenic mice were mated to the fertile males of ICR strain, but in almost all of them the vaginal plugs were not detected and their estrus cycles by vaginal smear 'were almost irregular which kept up estrus or diestrus stage. Many male transgenic mice did not have the ability of sexual behaviour. Therefore the viabilty of germ cells in infertile male transgenic mice was investigated by in vitro fertilization, but the sperm were normally fertilized with the eggs and the transgene of parent was passed on to the progeny. These results consequently suggest that the infertility of transgenic mice expressing human growth hormone gene (may be due to the physiological activity of human growth hormone, not germ cells.
ISSN
I000-0006
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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