Isolation of vindoline from Catharanthus roseus by supercritical fluid extraction

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Title
Isolation of vindoline from Catharanthus roseus by supercritical fluid extraction
Author(s)
Kyu-Min Song; Sang-Woo Park; Won-Hi Hong; Huen Lee; Sang Soo Kwak; Jang Ryol Liu
Bibliographic Citation
Biotechnology Progress, vol. 8, no. 6, pp. 583-586
Publication Year
1992
Abstract
Vindoline was extracted from the leaves of Catharanthus roseus over the ranges of 35-70 °C and 100-300 bar using supercritical carbon dioxide with and without the addition of 3 wt % ethanol as a cosolvent. The vindoline contents in the extracts were determined by HPLC and identified by LC/MS. The remarkable highest vindoline concentration, 58 wt %, was obtained at the lowest temperature, 35 °C, and the highest pressure, 300 bar, of this study. The use of a cosolvent only slightly improved the extraction yields or selectivities at some experimental conditions.
Keyword
supercritical fluid extractioncatharanthus roseusvindoline isolationvindolineisolation and purification
ISSN
8756-7938
Publisher
Wiley
DOI
http://dx.doi.org/10.1021/bp00018a018
Type
Article
Appears in Collections:
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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