Bioactive ellagitannins and phenylpropanoid glycosides from the seed of Torreya grandis

Abstract

Two new compounds, including one new ellagitannin, 4''-carboxyl-1,2,3,6-tetra-O-gally-β-D-glucopyranose (1), and a new phenylpropanoid glycoside, 7α-hydroxy-7β-8β-9axβ-9eqα(8,9-epoxy)-guaiacylglycerol 4-O-β-D- glucopyranoside.(8), have been isolated from the seed of Torreya grandis, together with eight known compounds (2？7, 9 and 10). Their structures were elucidated by the basis of NMR and HRFABMS. All the isolates were evaluated for in vitro inhibitory activity against DGAT1/2. Among them, compounds 1？7 displayed the significant inhibitory activities on DGAT1 with IC50 values ranging from 31.1 ± 1.1 to 118.5 ± 1.2 μM.