MT-2007, Protein Kinase C inhibitor from actinomycetes isolate No. 2007-18 = 방선균 분리주 No. 2007-18이 생산하는 Protein Kinase C 저해물질 , MT-2007

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dc.contributor.authorJong Seog Ahn-
dc.contributor.authorMoon-Su Park-
dc.contributor.authorSoon Cheol Ahn-
dc.contributor.authorChan Sun Park-
dc.contributor.authorWon Keun Oh-
dc.contributor.authorByung Dae Yoon-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorTae Ick Mheen-
dc.date.accessioned2017-04-19T08:44:25Z-
dc.date.available2017-04-19T08:44:25Z-
dc.date.issued1993-
dc.identifier.issn0257-2389-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/3327-
dc.description.abstractDuring the screening of inhibitors against protein kinase C(PKC) and the bleb formation of K562 cell induced by phorbol ester from microbial secondary metabolites, MT-2007 was purified by solvent extraction, and chromatographic techniques from Actinomycetes isolate No. 2007-18. It showed completely suppression of bleb formation of K562 cell surface induced by phorbol 12,13-dibutylate at the concentration of 503.9 μM and IC_50 on PKC was 31.4 μM. Its structure was postulated as lasalocid A sodium salt by physico-chemical properties and UV, IR, MS, ^1H-NMR.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleMT-2007, Protein Kinase C inhibitor from actinomycetes isolate No. 2007-18 = 방선균 분리주 No. 2007-18이 생산하는 Protein Kinase C 저해물질 , MT-2007-
dc.title.alternativeMT-2007, Protein Kinase C inhibitor from actinomycetes isolate No. 2007-18-
dc.typeArticle-
dc.citation.titleKorean Journal of (Applied) Microbiology & Biotechnology-
dc.citation.number1-
dc.citation.endPage58-
dc.citation.startPage54-
dc.citation.volume21-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorSoon Cheol Ahn-
dc.contributor.affiliatedAuthorChan Sun Park-
dc.contributor.affiliatedAuthorWon Keun Oh-
dc.contributor.affiliatedAuthorByung Dae Yoon-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.affiliatedAuthorTae Ick Mheen-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName박문수-
dc.contributor.alternativeName안순철-
dc.contributor.alternativeName박찬선-
dc.contributor.alternativeName오원근-
dc.contributor.alternativeName윤병대-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName민태익-
dc.identifier.bibliographicCitationKorean Journal of (Applied) Microbiology & Biotechnology, vol. 21, no. 1, pp. 54-58-
dc.subject.keywordActinomycetes-
dc.subject.keywordprotein kinase C inhibitor-
dc.subject.keywordlasalocid A-
dc.subject.localactinomycete-
dc.subject.localActinomycetes-
dc.subject.localactinomycetes-
dc.subject.localProtein kinase C inhibitor-
dc.subject.localprotein kinase c inhibitor-
dc.subject.localprotein kinase C inhibitor-
dc.subject.locallasalocid A-
dc.description.journalClassN-
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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