MT-2007, Protein Kinase C inhibitor from actinomycetes isolate No. 2007-18 = 방선균 분리주 No. 2007-18이 생산하는 Protein Kinase C 저해물질 , MT-2007
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jong Seog Ahn | - |
| dc.contributor.author | Moon-Su Park | - |
| dc.contributor.author | Soon Cheol Ahn | - |
| dc.contributor.author | Chan Sun Park | - |
| dc.contributor.author | Won Keun Oh | - |
| dc.contributor.author | Byung Dae Yoon | - |
| dc.contributor.author | Hyun Sun Lee | - |
| dc.contributor.author | Tae Ick Mheen | - |
| dc.date.accessioned | 2017-04-19T08:44:25Z | - |
| dc.date.available | 2017-04-19T08:44:25Z | - |
| dc.date.issued | 1993 | - |
| dc.identifier.issn | 0257-2389 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/3327 | - |
| dc.description.abstract | During the screening of inhibitors against protein kinase C(PKC) and the bleb formation of K562 cell induced by phorbol ester from microbial secondary metabolites, MT-2007 was purified by solvent extraction, and chromatographic techniques from Actinomycetes isolate No. 2007-18. It showed completely suppression of bleb formation of K562 cell surface induced by phorbol 12,13-dibutylate at the concentration of 503.9 μM and IC_50 on PKC was 31.4 μM. Its structure was postulated as lasalocid A sodium salt by physico-chemical properties and UV, IR, MS, ^1H-NMR. | - |
| dc.publisher | Korea Soc-Assoc-Inst | - |
| dc.title | MT-2007, Protein Kinase C inhibitor from actinomycetes isolate No. 2007-18 = 방선균 분리주 No. 2007-18이 생산하는 Protein Kinase C 저해물질 , MT-2007 | - |
| dc.title.alternative | MT-2007, Protein Kinase C inhibitor from actinomycetes isolate No. 2007-18 | - |
| dc.type | Article | - |
| dc.citation.title | Korean Journal of (Applied) Microbiology & Biotechnology | - |
| dc.citation.number | 1 | - |
| dc.citation.endPage | 58 | - |
| dc.citation.startPage | 54 | - |
| dc.citation.volume | 21 | - |
| dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
| dc.contributor.affiliatedAuthor | Soon Cheol Ahn | - |
| dc.contributor.affiliatedAuthor | Chan Sun Park | - |
| dc.contributor.affiliatedAuthor | Won Keun Oh | - |
| dc.contributor.affiliatedAuthor | Byung Dae Yoon | - |
| dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
| dc.contributor.affiliatedAuthor | Tae Ick Mheen | - |
| dc.contributor.alternativeName | 안종석 | - |
| dc.contributor.alternativeName | 박문수 | - |
| dc.contributor.alternativeName | 안순철 | - |
| dc.contributor.alternativeName | 박찬선 | - |
| dc.contributor.alternativeName | 오원근 | - |
| dc.contributor.alternativeName | 윤병대 | - |
| dc.contributor.alternativeName | 이현선 | - |
| dc.contributor.alternativeName | 민태익 | - |
| dc.identifier.bibliographicCitation | Korean Journal of (Applied) Microbiology & Biotechnology, vol. 21, no. 1, pp. 54-58 | - |
| dc.subject.keyword | Actinomycetes | - |
| dc.subject.keyword | protein kinase C inhibitor | - |
| dc.subject.keyword | lasalocid A | - |
| dc.subject.local | actinomycete | - |
| dc.subject.local | Actinomycetes | - |
| dc.subject.local | actinomycetes | - |
| dc.subject.local | Protein kinase C inhibitor | - |
| dc.subject.local | protein kinase c inhibitor | - |
| dc.subject.local | protein kinase C inhibitor | - |
| dc.subject.local | lasalocid A | - |
| dc.description.journalClass | N | - |
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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