Comparative studies of adriamycion and 28-deacetyl sedanin on in vitro growth inhibition of human cancer cell lines

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Title
Comparative studies of adriamycion and 28-deacetyl sedanin on in vitro growth inhibition of human cancer cell lines
Author(s)
Hwan Mook Kim; Goo Taeg Oh; Sang Bae Han; Dong Ho Hong; Bang Yeon Hwang; Young Ho Kim; Jung Joon Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 17, no. 2, pp. 100-103
Publication Year
1994
Abstract
The limonoid compound (28-deacetyl sendanin) isolated from the fruit of Melia toosendan SIEB. et ZUCC. was evaluated on anticancer activity. According to a standard in vitro cytotoxicity assay, eight human cancer cell lines and SRB assay were introduced for present evaluation. As a positive standard, adriamycin was tested in parallel. The cell lines were originated from six different organs. In view of dose-response profiles to 28-deacetyl sendanin, the most sensitive cells were SF-539 and PC-3 which were derived from CNS and prostate, respectively. In contrast, all the cell lines responded similarly to adriamycin to give rise to nearly identical dose-response profiles. By comparison of Gl50 between 28-deacetyl sendanin and adriamycin, six cell lines were more sensitive to 28-deacetyl sendanin and two were more resistant. As a result, 28-deacetyl sendanin had more sensitive and selective inhibitory effects on in vitro growth of human cancer cell lines in a comparison with adriamycin.
Keyword
28-deacetyl sendaninLimonoidMelia toosendan SIEB. et ZUCCAnticancerHuman cancer cellsSRB assayAdriamycin
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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