Tumor cell growth inhibition and antioxydative activity of flavonoids from the stem bark of Cudrania tricuspidata = 꾸지 뽕나무로부터 분리한 flavonoid계 화합물의 암세포성장 저해 및 항산화 활성

Abstract

Five cytotoxic and antioxidative flavonoids were isolated from the stem bark of Cudrania tricuspidata by consecutive purification using HP-20, silicagel and prep-HPLC. They were identified as taxifolin, orobol, eriodictyol, dihydrokaempferol and steppogenin by means of spectral studies. The antioxidative activities (IC50) assayed by TBA method of these compound 1∼5 to were 6, 3, 3, >50, and 10μg/ml, respectively. The effect on the growth inhibition (IC50) of these compounds against P388 cell line were found to be 0.18, 3.3, 15 and 6.2μg/ml, respectively in the order of compound 2 to 5.