Selection of high yielding mutant strains for the antifungal antibiotics KRF-001 = 항진균물질 KRF-001의 고생산성 변이주 분리

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Title
Selection of high yielding mutant strains for the antifungal antibiotics KRF-001 = 항진균물질 KRF-001의 고생산성 변이주 분리
Author(s)
Hang-Woo Lee; Moo-Kyung Kim; Sung Uk Kim; Kwang Hee Son; Song Hae Bok
Bibliographic Citation
Korean Journal of Biotechnology and Bioengineering, vol. 9, no. 4, pp. 378-384
Publication Year
1994
Abstract
An impr ved method for the selective isolation of high-yielding mutant strains for the production of antifungal mtibiotic KRF-001 was investigated. The mutant strain U. V 4, which produces high titer of KRF-001, vas selected on the high potency agar plate after ultraviolet light irradiation. The U. V 4 strain prod iced 2-fold more KRF-001 than the mother strain in production media. Large scale fermen-ta仕on was)erformed using the U. V 4 strain in 100^ fermenter. The antifungal antibiotic KRF-001 secreted into :ulture broth was detected by HPLC in 24hrs of fermentation.
ISSN
1225-7117
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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