Production of antifungal lipopeptide Iturin by Bacillus subtilis = Bacillus subtilis로부터 항진균 리포펩타이드 물질 Iturin의 생산

Abstract

Iturin, ; n antifungal lipopeptide, fermentation by Bacillus subtilis was investigated focusing on the effects of n itrients, aeration and specific cell growth rate on iturin production. Cell growth and product formation were not affected by different kinds of carbon sources such as sucrose, glucose and fructose. Soytone c)ncentration above 20g/^ did not influence iturin production. Diauxic growth pattern appeared wl en only soytone was used as a sole nitrogen sourse probably due to the shortage of amino acide and or peptides in soytone which could be favorably assimilated by the cells. The composition of three maj r components in iturin was not changed significantly by the variation of dissolved oxygen concentra ion of the culture broth, but changed substantially by the change of specific growth rate of the cells.