Direct exposure to 2,3,7,8-tetrachlodibenzo-p-dioxin(TCDD) increases infectivity of human erythrocytes to a malarial parasite

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dc.contributor.authorHwan Mook Kim-
dc.contributor.authorIn Pyo Choi-
dc.contributor.authorM P Holsapple-
dc.date.accessioned2017-04-19T08:44:41Z-
dc.date.available2017-04-19T08:44:41Z-
dc.date.issued1994-
dc.identifier.issn0024-3205-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/3461-
dc.description.abstractDirect exposure to 10 nM 2,3,7,8-TCDD caused a 75% increase and a 2-fold increase in the infectivity of isolated human erythrocytes to P. falciparum after 48 hours when the parasites were in an unsynchronized or synchronized state of growth, respectively. Treatment of human erythrocytes with 10 μM sodium orthovanadate (NaOV), an inhibitor of plasma membrane Ca-ATPase and phosphotyrosine phosphatase, decreased parasitemia by 30%. Co-treatment of RBCs with TCDD and NaOV completely blocked the TCDD-induced increase in parasitemia. Because erythrocytes are anucleated, these results are discussed as evidence for biochemical changes by TCDD without requiring the activation of gene products.-
dc.publisherElsevier-
dc.titleDirect exposure to 2,3,7,8-tetrachlodibenzo-p-dioxin(TCDD) increases infectivity of human erythrocytes to a malarial parasite-
dc.title.alternativeDirect exposure to 2,3,7,8-tetrachlodibenzo-p-dioxin(TCDD) increases infectivity of human erythrocytes to a malarial parasite-
dc.typeArticle-
dc.citation.titleLife Sciences-
dc.citation.number12-
dc.citation.endPage220-
dc.citation.startPage215-
dc.citation.volume54-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName최인표-
dc.contributor.alternativeNameHolsapple-
dc.identifier.bibliographicCitationLife Sciences, vol. 54, no. 12, pp. 215-220-
dc.description.journalClassY-
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Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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