The novel synthetic substance MR-387C [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-valyl- L-prolyl-L-leucine] as an aminopeptidase M inhibitor

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Title
The novel synthetic substance MR-387C [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-valyl- L-prolyl-L-leucine] as an aminopeptidase M inhibitor
Author(s)
Myung Chul Chung; Hyo Kon Chun; Ho Jae Lee; Yung Hee Kho
Bibliographic Citation
BMB Reports, vol. 28, no. 1, pp. 83-86
Publication Year
1995
Abstract
In the course of screening for new aminopeptidase M inhibitors which were expected to be analgesic, immunopotentiating, or anti-metastatic agents, the novel synthetic substance MR-387C[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-valyl-L-prolyl-L-leucine] (M.W. 504 daltons) was obtained. It was competitive with the substrate and had an value of () and an inhibition constant () of . This novel MR-387C was compared with various known inhibitors of aminopeptidase M. It inhibited the enzyme more strongly than any other microorganism-originated inhibitor, except probestin.
Keyword
Aminopeptidase Minhibitorsynthetic peptide
ISSN
1225-8687
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
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