Isolation and characterization of the caprine genomic β-lactoglobulin gene

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Title
Isolation and characterization of the caprine genomic β-lactoglobulin gene
Author(s)
Jaeman Kim; Ji-Young Kim; Kyungjin Kim; Myeong Hee Yu
Bibliographic Citation
Molecules and Cells, vol. 5, no. 3, pp. 209-216
Publication Year
1995
Abstract
In order to obtain a mammary tissue-specific promoter, the genomic clones of P-lactoglobulin, one of the milk-specific proteins, were isolated from a caprine genomic library. The nucleotide sequence and structure of the caprine p-lactoglobulin gene is highly conserved among ruminant species. The functionality and mammary cell-specific expression of the caprine BLG promoter was examined in an in vitro cell culture system. Deletion analysis of the upstream regulatory sequence suggests that mammary tissue-specificity and hormonal inducibility may be mediated by a distal upstream regulatoiy sequence above ?109 bp rather than by a proximal promoter.
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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