Sequences responsible for transcription termination of the mouse gastrin gene

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dc.contributor.authorMoon Jong Noh-
dc.contributor.authorSun Jung Kim-
dc.contributor.authorYong Koo Kang-
dc.contributor.authorOok Joon Yoo-
dc.date.accessioned2017-04-19T08:45:00Z-
dc.date.available2017-04-19T08:45:00Z-
dc.date.issued1995-
dc.identifier.issn1039-9712-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/3610-
dc.description.abstractTo identify the transcription termination elements in the mouse gastrin gene, we examined RNA transcripts after stable transfection of gastrin expression plasmids into the NIH3T3 cell line. The GT-repeat region at the 3'-flanking sequence of the mouse gastrin gene acted as a transcription terminator. When the GT-repeat unit was deleted from its site, the effect of termination disappeared. Further experiment, using serial deletion mutants, revealed that the 56-38 nucleotide upstream region from the GT-repeat unit also participated in transcription termination. We propose that the upstream region of the GT-repeat unit might be recognized as a pause site by the RNA polymerase II, and an abnormal DNA structure, derived from the GT-repeat unit, might function as a blockage of polymerase processivity.-
dc.publisherWiley-
dc.titleSequences responsible for transcription termination of the mouse gastrin gene-
dc.title.alternativeSequences responsible for transcription termination of the mouse gastrin gene-
dc.typeArticle-
dc.citation.titleBiochemistry and Molecular Biology International-
dc.citation.number6-
dc.citation.endPage1213-
dc.citation.startPage1205-
dc.citation.volume35-
dc.contributor.affiliatedAuthorSun Jung Kim-
dc.contributor.alternativeName노문종-
dc.contributor.alternativeName김선정-
dc.contributor.alternativeName강용구-
dc.contributor.alternativeName유욱준-
dc.identifier.bibliographicCitationBiochemistry and Molecular Biology International, vol. 35, no. 6, pp. 1205-1213-
dc.description.journalClassY-
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