DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bo Yeon Kim | - |
dc.contributor.author | Soon Cheol Ahn | - |
dc.contributor.author | Dae Ook Kang | - |
dc.contributor.author | Hack Ryong Ko | - |
dc.contributor.author | Won Keun Oh | - |
dc.contributor.author | Hyun Sun Lee | - |
dc.contributor.author | Tae Ick Mheen | - |
dc.contributor.author | Hyune Mo Rho | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.date.accessioned | 2017-04-19T08:45:00Z | - |
dc.date.available | 2017-04-19T08:45:00Z | - |
dc.date.issued | 1996 | - |
dc.identifier.issn | 0167-4889 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/3611 | - |
dc.description.abstract | Herbimycin A, an inhibitor of protein tyrosine kinases, dose-dependently reduced PDGF-induced inositol phosphates (IF,) accumulation without effect on phosphatidylethanol (PEt) formation in PLC-γ-overexpressing NIH 3T3 (NIH 3T3γ1) cells. The compound also reduced tyrosine phosphorylations of some proteins including PLC-γ1 in response to PDGF. On the other hand, phorbol 12-myristate 13-acetate (PMA)-induced phospholipase D (PLD) activation was reduced by herbimycin A in the cells, indicating that the pathways for PLD activation by PDGF and PMA are different from each other. Also, these results suggest that PLC-γ1 activation is not always an upstream event for PLD activation and that tyrosine phosphorylation of one or more proteins not affected by herbimycin A should be indispensable for PLD activation in PDGF-stimulated NIH 3T3γ1 cells. | - |
dc.publisher | Elsevier | - |
dc.title | Inhibition of PDGF-induced phospholipase C activation by herbimycin A | - |
dc.title.alternative | Inhibition of PDGF-induced phospholipase C activation by herbimycin A | - |
dc.type | Article | - |
dc.citation.title | Biochimica et Biophysica Acta-Molecular Cell Research | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 36 | - |
dc.citation.startPage | 33 | - |
dc.citation.volume | 1311 | - |
dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
dc.contributor.affiliatedAuthor | Soon Cheol Ahn | - |
dc.contributor.affiliatedAuthor | Dae Ook Kang | - |
dc.contributor.affiliatedAuthor | Hack Ryong Ko | - |
dc.contributor.affiliatedAuthor | Won Keun Oh | - |
dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
dc.contributor.affiliatedAuthor | Tae Ick Mheen | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.alternativeName | 김보연 | - |
dc.contributor.alternativeName | 안순철 | - |
dc.contributor.alternativeName | 강대욱 | - |
dc.contributor.alternativeName | 고학룡 | - |
dc.contributor.alternativeName | 오원근 | - |
dc.contributor.alternativeName | 이현선 | - |
dc.contributor.alternativeName | 민태익 | - |
dc.contributor.alternativeName | 노현모 | - |
dc.contributor.alternativeName | 안종석 | - |
dc.identifier.bibliographicCitation | Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1311, no. 1, pp. 33-36 | - |
dc.identifier.doi | 10.1016/0167-4889(95)00185-9 | - |
dc.subject.keyword | herbimycin A | - |
dc.subject.keyword | phospholipase Cγ1 | - |
dc.subject.keyword | phospholipase D | - |
dc.subject.keyword | plate-derived growth factor | - |
dc.subject.local | herbimycin A | - |
dc.subject.local | Phospholipase Cγ1 | - |
dc.subject.local | phospholipase Cγ1 | - |
dc.subject.local | phospholipase C-γ1 | - |
dc.subject.local | phospholipase D | - |
dc.subject.local | Phospholipase D | - |
dc.subject.local | plate-derived growth factor | - |
dc.description.journalClass | Y | - |
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