Agastaquinone, A new cytotoxic diterpenoid quinone from Agastache rugosa

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Title
Agastaquinone, A new cytotoxic diterpenoid quinone from Agastache rugosa
Author(s)
Hyeong Kyu Lee; Sei Ryang Oh; JO Lee; JIN-WOONG KIM; CHONG-OCK LEE
Bibliographic Citation
Journal of Natural Products, vol. 58, no. 11, pp. 1718-1721
Publication Year
1995
Abstract
A new diterpenoid quinone, agastaquinone [1], was isolated from the roots of Agastache rugosa. An oxime derivative [2] of agastaquinone was prepared with hydroxylamine hydrochloride. The structure of agastaquinone [1] was established as 7-hydroxy-12- methoxy-20-norabieta-1,5(10),6,812-pentaene-3,1,1,11-trione by spectroscopic techniques. Compounds 1 and 2 showed nonspecific cytotoic activities against several human cancer cell lines in vitro (A549, SK-OV-3, SK-MEL-2, XF198, and HCT15).
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np50125a011
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
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