Taxol and related compounds in Korean Native Yews(Taxus cuspidata)

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Title
Taxol and related compounds in Korean Native Yews(Taxus cuspidata)
Author(s)
Choi MS; Sang Soo Kwak; Jang Ryol Liu; Park YG; Lee MK; Ahn NH
Bibliographic Citation
Planta Medica, vol. 61, no. 3, pp. 264-266
Publication Year
1995
Abstract
The concentrations of taxol and related compounds in the bark and needles of Taxus cuspidata grown on Mt. Jiri, Mt. Sobaek, and Cheju Island, and T. cuspidata var. latifolia on Ullung Island in Korea were determined by high performance liquid chromatography (HPLC). The taxane content significantly varied with the location and plant part. The taxol content in the bark of native yews from Mt. Jiri and Mt. Sobaek was high when compared to that reported for Pacific yew (T. brevifolia), whereas bark from trees on Cheju and Ullung Islands contained a much lower level. Surprisingly, the needles from Cheju and Ullung Islands contained a much higher level of taxol (0.022% and 0.0173%, respectively) than those of intermountain locations (0.0058% to 0.0085%), on the basis of dry weight. The bark and needles of T. cuspidata var. latifolia on Ullung Island also contained relatively high concentrations of 10-deacetylbaccatin III, 0.0497% and 0.0545%, respectively, and indicated that environmental factors may affect the quantity. Taxol in the needles was confirmed by electrospray mass spectrometry. These results suggest that foliage from yew trees growing in their natural habitats on Cheju and Ullung Islands may provide a renewable source for taxol.
Keyword
10-deacetylbaccatin IIIHPLCT. cuspidata var. latifoliataxaceaetaxoltaxus cuspidata
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-958069
Type
Article
Appears in Collections:
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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