Genomic organization of purK and purE in Brevibacterium ammoniagenes ATCC 6872 : purE locus provides a clue for genomic evolution

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Title
Genomic organization of purK and purE in Brevibacterium ammoniagenes ATCC 6872 : purE locus provides a clue for genomic evolution
Author(s)
Sung-Oh Chung; Jin-Ho Lee; Se Yong Lee; Dae Sil Lee
Bibliographic Citation
FEMS Microbiology Letters, vol. 137, no. 2, pp. 265-268
Publication Year
1996
Abstract
From the genomic library of Brevibacterium ammoniagenes ATCC6872, the pitrE locus encoding 5′-phosphoribosyl-5-aminoimidazole (AIR) carboxylase (EC 4.1.1.21) was cloned and its nucleotide sequence was determined. From the sequence analysis, two distinct open reading frames (ORFs) in the sequence of the purE locus were identified as purK and purE genes (purK-purE). An in vivo translation experiment reconfirmed the purK and purE genes to be independent. The genomic organization in the purE locus of B. ammoniagenes is opposite to that of the bacteria Escherichia coli and Bacillus subtilis. However, it coincides with the fused genes (purKE) of higher organisms Sacckaromyces cerevisiae, Schizosaccharomyces pombe and Vigna aconitifolia. This suggests that the purE locus might be an intermediate form for genomic evolution of bacteria to higher organisms.
Keyword
Brevibacterium ammoniagenesGenomic organizationPurePurk
ISSN
0378-1097
Publisher
Oxford Univ Press
DOI
http://dx.doi.org/10.1111/j.1574-6968.1996.tb08116.x
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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