Gradual accumulation of mutations in precore core region of HBV in patients with chronic active hepatitis : implications of clustering changes in a small region of the HBV core region

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dc.contributor.authorGang Min Hur-
dc.contributor.authorYoon Ik Lee-
dc.contributor.authorDong Jin Suh-
dc.contributor.authorJae Heun Lee-
dc.contributor.authorYoung Ik Lee-
dc.date.accessioned2017-04-19T08:45:11Z-
dc.date.available2017-04-19T08:45:11Z-
dc.date.issued1996-
dc.identifier.issn0146-6615-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/3674-
dc.description.abstractThe sequence in the precore and core region of the hepatitis B virus (HBV) genome in the serum of five chronic active hepatitis patients at four different stages in each individual were studied by polymerase chain reaction and DNA sequencing to determine the prevalence and type of precore and core mutants in each chronic active hepatitis (CAH) patient. Gradual changes of the virus genome in each CAH patient in precore and core regions were identified. Except for the virus from one patient, the mutant viruses showed gradual changes of genome sequences, which resulted in the generation of stop codons at the precore and core region, causing the association of active hepatitis in each patient even in the presence of anti-HBe. Mutational hot spots in the core region, which includes a clustering of changes in a small region of 14 amino acids (codons 84-97 from the start of the core gene) were found in all patients. This region of mutational hot spots in the core might be a major target of cytotoxic T lymphocytes (CTL), which has evolved under the pressure of immune selections, and these mutants might play a important role in the pathogenesis of viral hepatitis.-
dc.publisherWiley-
dc.titleGradual accumulation of mutations in precore core region of HBV in patients with chronic active hepatitis : implications of clustering changes in a small region of the HBV core region-
dc.title.alternativeGradual accumulation of mutations in precore core region of HBV in patients with chronic active hepatitis : implications of clustering changes in a small region of the HBV core region-
dc.typeArticle-
dc.citation.titleJournal of Medical Virology-
dc.citation.number1-
dc.citation.endPage46-
dc.citation.startPage38-
dc.citation.volume48-
dc.contributor.affiliatedAuthorYoon Ik Lee-
dc.contributor.affiliatedAuthorYoung Ik Lee-
dc.contributor.alternativeName허강민-
dc.contributor.alternativeName이윤익-
dc.contributor.alternativeName서동진-
dc.contributor.alternativeName이재흔-
dc.contributor.alternativeName이영익-
dc.identifier.bibliographicCitationJournal of Medical Virology, vol. 48, no. 1, pp. 38-46-
dc.identifier.doi10.1002/(SICI)1096-9071(199601)48:1<38::AID-JMV6>3.0.CO;2-M-
dc.subject.keywordCytotoxic T lymphocytes (CTL)-
dc.subject.keywordHepatitis variation-
dc.subject.keywordPolymerase chain reaction-
dc.subject.keywordPrecoreicore region (pre-C/C)-
dc.subject.keywordVariation-
dc.subject.localcytotoxic T lymphocytes (CTL)-
dc.subject.localCytotoxic T-Lymphocytes-
dc.subject.localcytotoxic T lymphocyte(CTL)-
dc.subject.localcytotoxic T lymphocyte-
dc.subject.localCytotoxic T-lymphocytes-
dc.subject.localcytotoxic T-lymphocytes-
dc.subject.localcytotoxic T lymphocyte (CTL)-
dc.subject.localCytotoxic T lymphocytes (CTL)-
dc.subject.localCytotoxic T lymphocytes-
dc.subject.localHepatitis variation-
dc.subject.localPolymerase chain reaction-
dc.subject.localPolymerase chain reaction (PCR)-
dc.subject.localPolymerase Chain Reaction-
dc.subject.localpolymerase chain reaction-
dc.subject.localPrecoreicore region (pre-C/C)-
dc.subject.localVariation-
dc.description.journalClassY-
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