Preventative vaccination of nonhuman primates

Abstract

Vaccination constitutes one of the most important means of preventing infectious disease in captive nonhuman primates (NHPs). Vaccination protocols for NHPs vary, as they are mostly guided by institutional preference, infection pressure, local availability, and recommendations by non-peer reviewed resources. Currently, no updated literature review about vaccination options for NHP is available. Therefore, we provide a detailed overview of published vaccination options for NHP. Our findings demonstrate that, while there are often insufficient scientific data to justify their use, the core vaccines used in most NHP species confer protection against tetanus, rabies, and measles. Where information is available, efficacy expectations, adverse effects, dosages and frequency of administration are provided. We advocate that the decision to vaccinate NHP for less common diseases, for which an off-label vaccine is available, should be grounded in a comprehensive risk assessment. This assessment should consider factors specific to the individual animal, the vaccine, the housing institution, the epidemiology of the disease, and relevant regulatory and ethical considerations.