Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase III

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Title
Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase III
Author(s)
Yeon Jeong Kim; Jong Hoon Park; Kyung Sook Kim; Ji Eun Chang; Jung Hun Koh; Myung Hee Kim; Dong Hyo Chung; Tai Wha Chung; In Seong Choe; Young Choon Lee; Chul Ho Kim
Bibliographic Citation
Gene, vol. 170, no. 2, pp. 281-283
Publication Year
1996
Abstract
We have isolated and characterized the immediate (1651 bp) 5′-flanking region of the gene (GnT-III) encoding N-acetylglucosaminyltransferase III (GnT-III) from a human placental genomic library. Analysis of promoter elements shows a similarity to the 5′-flanking region of murine 1,4-galactosyltransferase. The sequence lacks obvious TATA elements and CCAAT boxes; however, putative regulatory sites, including 2 potential cAMP-response regulatory elements (CRE), 11 insulin-response element consensus sequences (IRE), 7 potential AP-2-binding sites, 2 SP1 consensus sequences (GC boxes) and 2 sequences similar to the half-palindromic glucocorticoid-responsive element (GRE), are present.
Keyword
Placental libraryPromoter elementTranscription factor
ISSN
0378-1119
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/0378-1119(95)00818-7
Type
Article
Appears in Collections:
Synthetic Biology and Bioengineering Research Institute > Genome Editing Research Center > 1. Journal Articles
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