Effects of gelatinized Maca on andropause symptoms in aged male mice

Abstract

Background and Objective: Although, Maca ( Lepidium meyenii) has gained worldwide attention as a powerful energizer that improves physical health and mental well-being and increases reproductive capability, the effects of Maca on andropause symptoms in experimental animals remain poorly understood. This study aimed to investigate the potential effects of gelatinized Maca on andropause symptoms in aged mice. Materials and Methods: Maca was administered orally to aged rats at dose levels of 0, 500 and 1,000 mg/kg/day for 4 weeks and its effects on clinical signs, body weight, reproductive organs, oxidative stress, testosterone content, lipid metabolism and muscle mass were examined. All statistical comparisons were made using a one-way analysis of variance followed by Dunnett's multiple comparison test and p<0.05 indicated significance. Results: The 4 week repeated oral administration of Maca to aged male mice resulted in a decrease in retroperitoneal fat and an increase in antioxidant enzyme SOD activity at doses of >= 500 mg/kg/day. Furthermore, there was an increase in the vastus lateralis muscle at a dose of 1,000 mg/kg/day. Notably, Maca treatment did not result in any adverse effects on general symptoms, body weight, reproductive organ weight and histopathology, oxidation-antioxidant balance, testosterone content, lipid metabolism and muscle mass at any of the tested doses. Conclusion: The results of this study suggested that gelatinized Maca is a safe natural substance that can help alleviate andropause symptoms. It may serve as a promising alternative therapy for individuals who cannot receive testosterone treatment due to its side effects.