Stimuli-responsive polymeric nanomedicine for enhanced cancer immunotherapy

Abstract

Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting anticancer response, has emerged as a promising approach for counteracting the evasive tactics of cancer cells. This study delves into the innovative realm of stimuli-responsive polymeric nanomedicines in the context of cancer immunotherapy. By capitalizing on the intricate landscape of the tumor microenvironment (TME), which orchestrates immune suppression and tumor progression, stimuli-responsive nanomedicines offer a tailored strategy to enhance therapeutic interventions. The aberrant features of the TME, which include factors such as low pH, inflammation, oxidative stress, and enzyme overexpression, serve as triggers for intelligent delivery systems facilitated by functional polymers. This dynamic approach has the potential to overcome the challenges faced by traditional nanoparticle-based immunotherapy techniques, presenting a platform to precisely optimize drug delivery within the tumor locale. As the synergistic interaction between stimuli-responsive polymeric nanomedicines and the TME unfolds, a novel horizon emerges to advance the efficacy of cancer immunotherapy while mitigating its associated limitations.